Facile synthesis and conformation of 3′-O,4′-C-methyleneribonucleosides

Abstract

Bicyclic nucleoside analogues, 3′-O,4′-C-methyleneribonucleosides 1, including thymine, cytosine, adenine and guanine nucleobases, were conveniently synthesized from D-glucose, and the ribofuranose ring of 1 was found to exist predominantly in a S-conformation by means of ¹H NMR and X-ray analysis.

References

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