Issue 23, 1999

Facile synthesis and conformation of 3′-O,4′-C-methyleneribonucleosides

Abstract

Bicyclic nucleoside analogues, 3′-O,4′-C-methyleneribonucleosides 1, including thymine, cytosine, adenine and guanine nucleobases, were conveniently synthesized from D-glucose, and the ribofuranose ring of 1 was found to exist predominantly in a S-conformation by means of 1H NMR and X-ray analysis.

Supplementary files

Article information

Article type
Paper

Chem. Commun., 1999, 2423-2424

Facile synthesis and conformation of 3′-O,4′-C-methyleneribonucleosides

S. Obika, K. Morio, Y. Hari and T. Imanishi, Chem. Commun., 1999, 2423 DOI: 10.1039/A907218G

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