Phomeketales A–F, six unique metabolites from the endophytic fungus Phoma sp. YN02-P-3

Xia-Nan Sang; Shao-Fei Chen; Gang Chen; Xiao An; Sheng-Ge Li; Xiao-Ni Li; Bin Lin; Jiao Bai; Hai-Feng Wang; Yue-Hu Pei

doi:10.1039/C6RA12509C

Phomeketales A–F, six unique metabolites from the endophytic fungus Phoma sp. YN02-P-3†

Xia-Nan Sang,^ab Shao-Fei Chen,^ab Gang Chen,^ab Xiao An,^ab Sheng-Ge Li,^ab Xiao-Ni Li,^ab Bin Lin,^cd Jiao Bai,^ab Hai-Feng Wang*^ab and Yue-Hu Pei*^ab

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^a Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China
E-mail: wanghaifeng0310@163.com, peiyueh@vip.163.com
Tel: +86-24-23986483

^b School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

^c Department of Medicinal Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China

^d Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China

Abstract

Phomeketales A–F (1–6), six new xyloketals, with unprecendented carbon substitution at C-16 and C-17 simultaneously, were isolated from the endophytic fungus Phoma sp. YN02-P-3. Their structures were elucidated on the basis of 1D and 2D NMR spectral data and ECD analysis. Compound 3 exhibited moderate anti-AChE activity and cytotoxicity against HL-60.

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Phomeketales A–F, six unique metabolites from the endophytic fungus Phoma sp. YN02-P-3†

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Phomeketales A–F, six unique metabolites from the endophytic fungus Phoma sp. YN02-P-3

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