Synthesis of multisubstituted furans via Cu(i)-catalyzed annulation of ketones with alkynoate under ligand- and additive-free conditions

Abstract

A facile and efficient annulation strategy for the synthesis of multisubstituted furan derivatives has been achieved under mild conditions. The developed transformation via C(sp³)–H bond functionalization catalyzed by copper(I) salts using benzoyl peroxide as an external oxidant possess some obvious advantages. This ligand- and additive-free cyclization protocol offers an environmentally friendly and efficient access to biologically important scaffolds from readily available substrates.