Bifunctional thiourea catalyzed asymmetric Michael addition of anthrone to methyleneindolinones†
Abstract
Biologically significant hybrid derivatives of oxindoles and anthrones were prepared in high yield, high regioselectivity and high stereoselectivity via bifunctional thiourea catalyzed asymmetric conjugate addition of anthrone to methyleneindolinones. The regioselectivity and stereoselectivity could be finely tuned via change of substituents in methyleneindolinones.