Issue 23, 2016

Novel bioluminescent coelenterazine derivatives with imidazopyrazinone C-6 extended substitution for Renilla luciferase

Abstract

Two series of novel coelenterazine analogues (alkynes and triazoles) with imidazopyrazinone C-6 extended substitution have been designed and synthesized successfully for the extension of bioluminescent substrates. After extensive evaluation, some compounds display excellent bioluminescence properties compared with DeepBlueC in cellulo, thus becoming potential molecules for bioluminescence techniques.

Graphical abstract: Novel bioluminescent coelenterazine derivatives with imidazopyrazinone C-6 extended substitution for Renilla luciferase

Supplementary files

Article information

Article type
Paper
Submitted
28 Mar 2016
Accepted
11 May 2016
First published
11 May 2016

Org. Biomol. Chem., 2016,14, 5272-5281

Novel bioluminescent coelenterazine derivatives with imidazopyrazinone C-6 extended substitution for Renilla luciferase

T. Jiang, X. Yang, X. Yang, M. Yuan, T. Zhang, H. Zhang and M. Li, Org. Biomol. Chem., 2016, 14, 5272 DOI: 10.1039/C6OB00659K

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