Holger
Braunschweig
*a,
Ivo
Krummenacher
a,
Lisa
Mailänder
a,
Leanne
Pentecost
b and
Alfredo
Vargas
b
aInstitut für Anorganische Chemie, Julius-Maximilians-Universität Würzburg, Am Hubland, 97074 Würzburg, Germany. E-mail: h.braunschweig@uni-wuerzburg.de
bDepartment of Chemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, Sussex, UK
First published on 9th May 2016
Herein, we describe the selective formation of a stable neutral spiroborate radical by one-electron oxidation of the corresponding tetraorganoborate salt Li[B(C4Ph4)2], formally containing a tetrahedral borate centre and a s-cis-butadiene radical cation as the spin-bearing site. Spectroscopic and computational methods have been used to determine the spin distribution and the chromism observed in the solid state.
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Scheme 1 Two examples of oxidation reactions of organoborate salts resulting in C–C coupled products. |
Spiroborate 2 was synthesised as previously reported by our group by salt elimination of two equivalents of 1,2-dilithio-1,2,3,4-tetraphenylbutadiene with BF3·Et2O.8 Whereas the redox chemistry of boroles, five-membered boron-containing, antiaromatic and highly Lewis acidic heterocycles,9 has been explored extensively,10 the redox behaviour of the related spiroborate salt 2 had not been investigated so far. As judged by cyclic voltammetry in tetrahydrofuran solution, compound 2 undergoes an irreversible oxidation at −0.35 V vs. the [FeCp2]/[FeCp2]+ couple (see ESI†) in the potential window. We wondered if the oxidation step could be realised on a preparative scale and if the formed product could be isolated. To this end, a stoichiometric amount of the one-electron oxidation agent ferrocenium hexafluorophosphate was added to a solution of 2 in benzene at rt (Scheme 2). Addition of the Fe(III) salt led to an immediate colour change from yellow to dark green and the precipitation of a colourless solid. Upon completion, the 11B NMR resonance of the starting material (2, δB = −1.4 ppm) disappeared without the occurrence of a new signal. Similarly, the 1H NMR spectrum of the crude reaction mixture showed only the formation of ferrocene but no additional signals for the oxidation product. After the separation of Li[PF6] and ferrocene, compound 3 was isolated as green amorphous, or alternatively, red crystalline, solids (80% crystalline yield).
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Scheme 2 Oxidation of spiroborate salt 2 with [FeCp2][PF6] to radical 3 (only one possible resonance form is drawn). |
The absence of NMR signals suggested the radical character of 3, which was supported by EPR spectroscopy (vide infra). X-ray diffraction of red single crystals of 3 confirmed the formation of a charge-neutral species, consistent with a one-electron oxidation of spiroborate 2.8 The D2d symmetry is lifted in the oxidised product as can be seen by the changes of the geometric parameters around the spiro boron atom (cf. Table S1 in the ESI†). For instance, the two essentially planar BC5 rings in 3 deviate significantly from a perpendicular arrangement (79.0(1)°) and are displaced relative to each other from the twofold axis (Fig. 1, right). In addition, the one-electron oxidation leads to a shortening of the B–C distances of about 0.1 Å (3: ØB–C = 1.535 Å vs.2: ØB–C = 1.631 Å) and to a reduction in the bond length alternation of the bicyclic rings. The formal double bonds of the borate anion (C1–C2, C3–C4, C5–C6, and C7–C8) are elongated in the oxidised product 3, consistent with removal of an electron from the HOMO of the anion (2) which shows π-bonding interactions between these carbon atoms.
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Fig. 1 Left: Molecular structure of 3 in the solid state. Hydrogen atoms and the ellipsoids of the phenyl residues are omitted for clarity. The ellipsoids are set to 50% probability. For bond lengths and angles see Table S1 in the ESI.† Right: Side view showing the relative arrangement of the BC4 rings. |
The phenyl substituents around the spirocycle are arranged in a propeller-like manner as observed for 2. However, it is important to note that the phenyl ring at C1 is only tilted by 30.2° with respect to the fused ring plane, whereas the other aryl substituents have torsion angles between 43 and 69°. This might be due to effects of molecular packing or to some degree of spin delocalisation into the aryl π system.
The continuous-wave ESR spectrum of 3 in benzene solution shows that the unpaired spin density is delocalised into the aryl substituents (Fig. 2). The best-fit parameters for the second-derivative ESR signal (giso = 2.003) relate to small proton hyperfine couplings (in the range of 0.05–0.15 mT) of four equivalent phenyl groups, indicating simultaneous delocalisation of the unpaired spin density over both π planes. The ESR results thus point to a spiroconjugated organic radical with a structure of higher symmetry (D2d) than observed in the solid state.11
The UV-vis spectrum of 3 differs strongly from that of the borate salt 2, which shows a lowest absorption maximum at 365 nm (ε = 34490 L mol−1 cm−1).8 In addition to bands in the same wavelength region (λ(ε) = 329 nm (24
894 L mol−1 cm−1), λ(ε) = 352 nm (22
919 L mol−1 cm−1)), radical 3 exhibits additional transitions at lower energies (λ(ε) = 463 nm (12
967 L mol−1 cm−1), λ(ε) = 572 nm (2442 L mol−1 cm−1), λ(ε) = 604 nm (2307 L mol−1 cm−1), λ(ε) = ∼700.0 nm (∼750 L mol−1 cm−1)), which are extended into the near infrared range. The bands between 500–900 nm are significantly weaker in intensity than those between 300–500 nm and likely can be attributed to intervalence charge transfer transitions. The absorptions from 550 nm to the near IR range are consistent with other organic monoradicals.12–14
Another interesting aspect of this radical species is that its colour is strongly dependent on its physical state. The radical (3) is dark green in solution and in its amorphous solid state, whereas it is red in the crystalline state. Presumably, the locked conformation in the crystal structure limits the amount of π conjugation in the molecule, thus leading to a shift of the maximum absorption to shorter wavelengths.
Additional computational studies within the Kohn–Sham density functional theory (DFT) were undertaken. These calculations support the experimental results with respect to the generation of the radical species. Calculated structures of 2 and 3 were in reasonable agreement with those obtained experimentally (see ESI† for Computational details).
Energy minimisation calculations on 3 yielded structures in the gas phase that are distinct from the solvated structures. Furthermore, excited state calculations on the resulting geometries revealed different absorption profiles. These results strongly suggest environment-dependent geometries which in turn dictate the observed absorption profile – explaining the experimentally observed differing colours of the species depending on the physical state. Indeed, depending on the structure, e.g. the solvated structure, lower molecular orbitals are involved in the excitation process. Such observations lead to the idea of environment (e.g. solvent)-stabilised charge distribution within the system, which is further supported by computational results as shown by molecular electrostatic potentials (MEP) and natural charges. Further discussions on the theoretical results are given in the ESI.† Moreover, these calculations allowed identification of the experimentally observed transitions: HOMO−2 to LUMO (spin-down) at around 15500 cm−1 (645 nm), and HOMO to LUMO (spin-up) at around 21
000 cm−1 (476 nm).
Another geometry-dependent feature of 3 is that of the spin-density distribution, which unsurprisingly is dictated by the structure. Calculations show that the spin population in the radical is essentially localised on one borole moiety in both the gas and solution phase; the dominant spin density is found on the two carbon atoms adjacent to the boron atom. Imposing D2 symmetry distributes the spin density evenly on all four carbon atoms adjacent to the boron atom that extends into the phenyl substituents. Furthermore, in this symmetrical configuration the molecular orbitals (MOs) are delocalised across both borole moieties (see Fig. 3). Both the spin density and MO profiles are well in line with experimental results (vide supra). The total electronic energy of the symmetrised structure is only slightly (0.6 kcal mol−1) higher than that of the non-symmetrised structure. This could be ascribed in part to interaction of the two perpendicular π planes connected by the boron centre, via so-called spiroconjugation.15
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Fig. 3 MO62X/6-311G* calculated (a) singly-occupied molecular orbital (SOMO), and (b) spin-density distribution for 3 with imposed D2 symmetry. |
The difference in reactivity of 2 compared to its benzannelated analogue 1, the latter undergoing coupling of the organic substituents upon oxidation,4,5 most likely arises from the stoichiometric use of the outer-sphere oxidant ferrocenium, which can accept precisely one electron from the borate. Isolation of the stable spiro radical (3) suggests that a radical mechanism might be operative in the oxidative ligand coupling of other organoborates, as previously proposed.4,5,7 The possible resonance forms of the zwitterionic species 3 all consist of a borate anion and a s-cis-1,3-butadiene radical cation bearing the unpaired spin density (see Scheme 1). The structure thus draws immediate comparison to simple butadiene radical cations which have attracted considerable theoretical and experimental attention,16 but have eluded characterisation by X-ray crystallography thus far.17 Moreover, radical 3 resembles the structures of the neutral radicals reported by Haddon and coworkers,18 in which two phenalenyl units are attached to a tetrahedral boron atom. In this family of compounds, however, the neutral spiro radical is based on N,N- or N,O-containing six-membered heterocyclic systems and is thus not susceptible to a competing oxidative ligand coupling reaction. Closely related to 3 are also the neutral borocyclic radicals of the general formula [(C6F5)2B(O2C14H8)]˙ and [(C6F5)2B(O2C16H8)]˙ in which the boron atom has two oxygen substituents.19
In summary, we have shown that by chemical one-electron oxidation of an organoborate, a neutral stable radical of the form [BR4]˙ can be generated. The stability and persistence of the radical species enabled its characterisation by X-ray crystallography, in addition to spectroscopic techniques (ESR and UV-vis). Assisted by DFT and TD-DFT calculations, the striking colour change between the crystalline and the solution/amorphous state could be attributed to structural changes of the spiro compound. Further investigations regarding the intriguing electronic and optical properties of the compound, as well as its reactivity, are underway.
We thank the Deutsche Forschungsgemeinschaft (H. B.), the University of Sussex and the EPSRC (A. V.) for support of this work.
Footnote |
† Electronic supplementary information (ESI) available: Experimental details, additional crystallographic, computational and electrochemical data. CCDC 1469228. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6cc02916g |
This journal is © The Royal Society of Chemistry 2016 |