Ali Pourjavadi*a,
Seyed Hassan Hosseinia,
Firouz Matloubi Moghaddamb and
Seyed Ebrahim Ayatib
aPolymer Research Laboratory, Department of Chemistry, Sharif University of Technology, Tehran, Iran. E-mail: purjavad@sharif.edu; Fax: +98 2166165311; Tel: +98 2166165311
bLaboratory of Organic Synthesis and Natural Products, Department of Chemistry, Sharif University of Technology, Tehran, Iran
First published on 6th March 2015
A novel heterogeneous copper catalyst was synthesized in which poly(1-vinyl imidazole-co-ionic liquid) was used as a solid heterogeneous support. The catalyst was readily synthesized in a large scale amount. The catalyst has a high loading level of copper ions and can be used in low weight percentages. The resulting catalyst was highly active in the preparation of triazoles by the Huisgen 1,3-dipolar cycloaddition method. In some cases the catalytic turnover number and frequency reached 70002 and 3889 h−1, respectively. The catalyst was recycled many times without significant loss of activity.
On the other hand, decreasing the amount of used copper catalysts in catalytic reactions is very important for industrial applications. Increasing the amount of used catalyst caused more pollution of catalyst and more solvent needs for reaction, separation process and recovery of catalyst. Therefore, developing an effective heterogeneous copper catalyst with high stability, low leaching, high loading and cleaner catalytic system is still demanded.
Herein, we describe the synthesis of copper loaded cross-linked ionic-imidazole polymer as a simple, inexpensive, and high loaded and efficient heterogeneous catalyst for use in the synthesis of 1,2,3-triazoles. Copper metalloenzymes are generated by complexation of imidazole of histidine amino acid in peptide structure and copper ion and these complexations are important in enzymatic reactions.35,36 Therefore, investigation in catalytic activity of imidazole–copper polymer is one of the most interesting topics in polymer chemistry.
FT-IR spectra of samples were taken using an ABB Bomem MB-100 FTIR spectrophotometer. Thermogravimetric analysis (TGA) was acquired under a nitrogen atmosphere with a TGA Q 50 thermogravimetric analyzer. The morphology of the catalyst was observed using a Philips XL30 scanning electron microscope (SEM).
The resulting powdered materials were subjected to anion exchange reaction. 0.3 g of powdered P[im/IL][Cl] was added to 50 mL water and an excess amount of salt (10 fold than Cl anions in P[im/IL][Cl]) was added to the solution. The mixture was vigorously stirred (1000 rpm) for 3 days at room temperature. The solid products were then filtered, washed five times with water (5 × 100 mL) and twice with methanol (2 × 20 mL) and dried in vacuum at 50 °C.
0.5 g P[im/IL][Cl] was dispersed in 20 mL aqueous solution of CuSO4 (Cu(II) mmol in solution was 0.5 fold of imidazole groups) by ultra-sonication for 25 min. Then the resulting mixture was stirred at 70 °C for 24 h. Afterward, the solid blue products were filtered and washed with water (5 × 50 mL) and dried at 50 °C to give P[imCu/IL][Cl]. The procedure for synthesis of other catalysts is the same as above method.
The FT-IR spectrum of P[im/IL][Cl] shows the stretching vibration bands at 1644, 1495, 1233 cm−1 which are attributed to carbonyl groups of MAPTAC and CN, C
C and C–N of imidazole rings, respectively. The peak at 2927 cm−1 is attributed to C–H of alkyl chains (Fig. 2). The FT-IR spectra of ion exchanged products are presented at ESI (Fig. S1†).
Similar pattern was observed in the FTIR spectrum of copper loaded catalyst (P[imCu/IL][Cl]) and a new peak also appeared at 1108 cm−1 which is attributed to SO4 anions of CuSO4 (Fig. 2). The result confirms that CuSO4 was successfully absorbed on the cross-linked copolymer.
Fig. 3 shows the thermal gravimetric analysis (TGA) and differential thermal analysis (DTA) of P[imCu/IL][Cl]. The weight loss at 150 °C was attributed to the loss of adsorbed water molecules in cross-linked polymer. The decomposition of catalyst started at 280 °C and it was completely decomposed at 450 °C. This result demonstrates that catalyst is stable at range 25–280 °C which is absolutely suitable for various catalytic reactions. DTA curve shows three distinct peaks at 90, 320 and 450 °C which are attributed to adsorbed water molecules, MAPTAC and imidazole parts in polymer structure, respectively.
The SEM image of catalyst shows a rough surface for P[imCu/IL][Cl] (Fig. 4). This surface morphology improves the catalyst activity due to the higher penetration of substrates onto the catalyst. EDX analysis also shows the presence of copper ion in catalyst structure (Fig. 4).
Atomic absorption and ICP-AES showed that the loading amount of copper ion in catalyst structure is about 1.3 mmol g−1. The high loading level of immobilized copper ion resulted to using lower weight percent of catalyst in reaction. This feature of catalyst is especially useful when the catalyst is applied in large scale production.
Table 1 shows the control experiment and optimization of catalytic reaction by choosing reaction between phenyl acetylene benzyl bromide and sodium azide as model reaction. As seen in Table 1 without catalyst only a small amount of triazole product was obtained even by increasing reaction temperature to 70 °C. Moreover, P[im/IL][Cl] did not show any catalytic effect and less than 12% product was obtained at 100 °C in 8 h. On the other hand, homogenous copper(II) sulfate increased the reaction yield up to 28% at 55 °C. Increasing the reaction temperature up to 110 °C gave 87% yield in 24 h. But in this case mixtures of two regioisomers were obtained. In the next step catalytic performance of P[imCu/IL][Cl] was investigated and it was found that using 0.7 mol% of P[imCu/IL][Cl] increased the reaction yield to 99% in 2 h at 55 °C. To investigate the effect of anion, various catalysts with different anions were examined and the results are presented in Table 1 entries 6–10. As a result, we observed that the order of catalytic activities of the five catalysts were; Cl > OAc > Br > BF4 > NO3. This order of catalytic activity can be attributed to atomic radius of anions and chelation of copper ion by anions. Larger anions reduce substrates penetration onto the polymer network due to larger steric effect. Therefore, chloride counterion with smaller size gave better yield. On the other hand more basic anions like Cl and OAc can chelate copper ions better than less basic ones. Therefore, the transition state of reaction is more stable when P[imCu/IL][Cl] is used than P[imCu/IL][NO3].
Entry | Catalyst | Cat. loading (mol%) | Solvent | T (°C) | Time (h) | Yieldb (%) | TOF (h−1) |
---|---|---|---|---|---|---|---|
a Reaction condition: phenyl acetylene (1 mmol), benzyl bromide (1 mmol), sodium azide (1.2 mmol), sodium ascorbate (10 mol%), solvent (3 mL).b Isolated yield.c The ratio of H2O/t-BuOH is 3/1.d Mainly recovery of the starting materials.e Mixture of regioisomers.f 10 mmol scale of reaction.g Cross-linked poly(vinyl imidazole) was used. Loading amount of copper on P[imCu] is 0.61 mmol g−1.h Catalyst: mixture of vinyl imidazole (2 eq.) and copper sulfate (1 eq.). | |||||||
1 | — | — | H2O–t-BuOHc | r.t | 24 | <1d | — |
2 | — | — | H2O–t-BuOH | 70 | 8 | <3d | — |
3 | P[im/IL][Cl] | 10 mg | H2O–t-BuOH | 100 | 8 | <12d | — |
4 | CuSO4 | 5 | H2O–t-BuOH | 55 | 10 | 28 | 0.6 |
5 | CuSO4 | 5 | H2O–t-BuOH | 110 | 10 | 87e | 2 |
6 | P[imCu/IL][Cl] | 0.7 | H2O–t-BuOH | 55 | 2 | 99 | 71 |
7 | P[imCu/IL][Br] | 0.7 | H2O–t-BuOH | 55 | 2 | 83 | 59 |
8 | P[imCu/IL][NO3] | 0.7 | H2O–t-BuOH | 55 | 2 | 72 | 51 |
9 | P[imCu/IL][OAc] | 0.7 | H2O–t-BuOH | 55 | 2 | 88 | 63 |
10 | P[imCu/IL][BF4] | 0.7 | H2O–t-BuOH | 55 | 2 | 73 | 52 |
11 | P[imCu/IL][Cl] | 0.7 | H2O–t-BuOH | r.t | 2 | 80 | 57 |
12 | P[imCu/IL][Cl] | 0.7 | H2O–t-BuOH | r.t | 9 | 99 | 16 |
13 | P[imCu/IL][Cl] | 0.4 | H2O–t-BuOH | 55 | 2 | 99 | 124 |
14 | P[imCu/IL][Cl] | 0.1 | H2O–t-BuOH | 55 | 2 | 99 | 495 |
15 | P[imCu/IL][Cl] | 0.0013 | H2O–t-BuOH | 55 | 18 | 91f | 3889 |
16 | P[imCu/IL][Cl] | 0.1 | H2O | 55 | 2 | 91 | 455 |
17 | P[imCu/IL][Cl] | 0.1 | t-BuOH | 55 | 4 | 81 | 203 |
18 | P[imCu/IL][Cl] | 0.1 | CH3CN | 55 | 4 | 83 | 208 |
19 | P[imCu/IL][Cl] | 0.1 | CH3OH | 55 | 4 | 69 | 173 |
20 | P[imCu/IL][Cl] | 0.1 | Toluene | 55 | 4 | 37 | 93 |
21 | P[imCu]g | 0.1 | H2O–t-BuOH | 55 | 2 | 79 | 385 |
22 | Vim/Cuh | 0.1 | H2O–t-BuOH | 55 | 2 | 99 | 495 |
Since first step of the reaction is nucleophilic substitution of sodium azide to benzyl bromide, basic anions such as Cl and OAc can chelate Na+ in NaN3 and increase the reaction rate for first step and increase the yield of product.
Entry 11 shows that reducing the reaction temperature to room temperature reduced the yield of triazole product at the same reaction time. However, we found that in same condition longer time is required for completion of reaction (entry 12). The optimization of catalyst loading in reaction shows that catalyst is highly active and even 0.1 mol% is enough for reaction and 99% yield is obtained at 55 °C. We decreased the catalyst amount to 0.0013 mol% (130 mol ppm) and surprisingly it was observed that reaction is completed with 91% yield and the turnover frequency of catalyst reached to 3889 h−1. This result shows the high efficiency of P[imCu/IL][Cl] in Huisgen reaction.
Same reaction was performed in various solvents but 3/1 ratio of H2O/t-BuOH shows the best result. It can be seen that the result of catalytic reaction in pure water (entry 16) is as well as using mixture of solvents. This result provides a greener protocol for Huisgen reaction in water.
Entry 21 shows the effect of the presence of ionic monomer in the catalyst structure. It also can be seen that copper is adsorbed to poly(vinyl imidazole) less than ionic catalysts. Therefore, ionic monomer not only improves the catalytic performance but also increase copper adsorption and reduced the amount of used catalyst in the reaction.
To investigate the effect of imidazole groups as ligand we used the mixture of vinyl imidazole and copper sulfate in ratio of 2:
1 as a homogenous catalyst. The result showed that imidazole groups increased the activity of copper by complexation (entry 22). However, this catalyst is effective but it is a homogenous catalyst and its separation from the solution is an issue.
In continue, the scope of three-component reaction of alkyl halide, sodium azide and alkyne catalyzed by P[imCu/IL][Cl] was investigated on a number of assorted substrates in optimized condition (Table 2). Various substrates with electron withdrawing and electron donating groups reacted under optimized condition and gave corresponding triazoles in satisfactory yields. Compared to aryl substrates, reaction of alkyl substrates were slightly slower, although the yields of products were still excellent. These results show that P[imCu/IL][Cl] is a powerful catalyst for the synthesis of a broad range of triazoles.
Entry | Alkyne | Alkyl/Aryl halide | Product | Time (h) | Yieldb (%) |
---|---|---|---|---|---|
a Reaction condition: alkyne (0.5 mmol), alkyl halide (0.5 mmol), NaN3 (1 mmol), sodium ascorbate (10 mol%), P[imCu/IL][Cl] (0.1 mol%), solvent (H2O/t-BuOH, 3/1), 55 °C.b Isolated yield. | |||||
1 | ![]() |
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2 | 99 |
2 | ![]() |
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4 | 98 |
3 | ![]() |
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2 | 99 |
4 | ![]() |
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1.5 | 96 |
5 | ![]() |
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3.5 | 97 |
6 | ![]() |
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5 | 98 |
7 | ![]() |
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4 | 96 |
8 | ![]() |
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8 | 94 |
9 | ![]() |
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3.5 | 98 |
10 | ![]() |
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3 | 93 |
11 | ![]() |
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3 | 94 |
12 | ![]() |
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2 | 97 |
13 | ![]() |
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4 | 93 |
14 | ![]() |
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5 | 98 |
15 | ![]() |
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6 | 90 |
16 | ![]() |
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5 | 89 |
17 | ![]() |
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2 | 90 |
18 | ![]() |
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4 | 96 |
19 | ![]() |
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3 | 95 |
20 | ![]() |
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4 | 95 |
21 | ![]() |
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6 | 96 |
22 | ![]() |
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3 | 94 |
23 | ![]() |
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3 | 95 |
24 | ![]() |
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6 | 90 |
25 | ![]() |
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2 | 92 |
26 | ![]() |
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4 | 90 |
27 | ![]() |
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3 | 95 |
28 | ![]() |
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3 | 95 |
29 | ![]() |
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4 | 92 |
30 | ![]() |
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3 | 93 |
31 | ![]() |
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2 | 95 |
32 | ![]() |
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3 | 95 |
33 | ![]() |
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3 | 91 |
34 | ![]() |
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3 | 86 |
35 | ![]() |
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4 | 90 |
36 | ![]() |
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4 | 85 |
Along with the high activity of P[imCu/IL][Cl] in a low weight percent, another useful advantage of the catalyst is its reusability. At the end of a reaction, the catalyst was easily separated from solution by simple filtration. The reusability of P[imCu/IL][Cl] was investigated in three component reaction between phenyl acetylene, benzyl bromide and sodium azide as model reaction (Table 2, entry 1). In order to prevent catalyst mass losing, at the end of each cycle the catalyst was separated by centrifuge, washed and dried for next runs. As shown in Fig. 5 the catalyst was reused 12 times and no significant loss of activity was observed.
In order to investigate catalyst leaching, reaction between phenyl acetylene, benzyl bromide, NaN3 was chosen as model reaction. The reaction was performed in optimized condition and after half of the reaction time (60 min) the catalyst was separated from the solution by hot filtration using hot ethyl acetate. The rest of reaction mixture (in the absence of catalyst) was allowed to stir for another 60 min. As seen in Fig. 6 no triazole was produced after catalyst removal. Moreover, atomic absorption analysis of triazole product shows no copper ion in it. These results show that catalyst is truly heterogeneous and catalyst leaching is negligible under reaction condition.
Footnote |
† Electronic supplementary information (ESI) available. See DOI: 10.1039/c5ra00127g |
This journal is © The Royal Society of Chemistry 2015 |