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Correction: Design and chemoproteomic functional characterization of a chemical probe targeted to bromodomains of BET family proteins
Jiang
Wu
a,
Julia
Shin
b,
Cara M. M.
Williams
b,
Kieran F.
Geoghegan
a,
Stephen W.
Wright
c,
David C.
Limburg
c,
Parag
Sahasrabudhe
a,
Paul D.
Bonin
e,
Bruce A.
Lefker
*d and
Simeon J.
Ramsey
b
aStructural Biology and Biophysics, Worldwide Medicinal Chemistry, Pfizer, Groton, CT 06340, USA
bInflammation and Remodeling Research Unit, Pfizer, Cambridge, MA 02139, USA
cWorldwide Medicinal Chemistry, Pfizer, Groton, CT 06340, USA
dWorldwide Medicinal Chemistry, Pfizer, 610 Main Street, Cambridge, MA 02139, USA. E-mail: bruce.a.lefker@pfizer.com; Fax: +1 860-715-8059; Tel: +1 617-674-7450
ePrimary Pharmacology Group, Pfizer, Groton, CT 06340, USA
First published on 8th December 2014
Abstract
Correction for ‘Design and chemoproteomic functional characterization of a chemical probe targeted to bromodomains of BET family proteins’ by Jiang Wu et al., Med. Chem. Commun., 2014, 5, 1871–1878.
The following scheme captions were missing from the paper:
Scheme 1 (a) 2-ethyl-4,4-dimethyl-4,5-dihydroxazole, NaHSO4, NMP, xylenes, 200 °C, 93%; (b) 10% Pd/C, acetic acid, 84%; (c) 2-methoxybenzenesulfonyl chloride, pyridine, 46%.
Scheme 2 (a) acrylonitrile, NaOH, 26%; (b) Adam's catalyst, ethanol, CHCl3, 99%; (c) di-tert-butyl dicarbonate, TEA, THF, 37%; (d) 6, polymer bound TPP, DIAD, 79%; (e) benzyltrimethylammonium chloride, trichloroisocyanuric acid, H2O, ACN, 92%; (f) 5, pyridine, 68%; (g) TFA, CH2Cl2, 0–20 °C, 100%; (h) desthiobiotin, DMF, DIEA, HATU, 15%.
The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.
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