Erli
Lu
and
Stephen T.
Liddle
*
School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. E-mail: stephen.liddle@nottingham.ac.uk
First published on 23rd June 2015
Oxidative addition, and its reverse reaction reductive elimination, constitute two key reactions that underpin organometallic chemistry and catalysis. Although these reactions have been known for decades in main group and transition metal systems, they are exceptionally rare or unknown for the f-block. However, in recent years much progress has been made. In this Perspective article, advances in uranium-mediated oxidative addition/reductive elimination, since the point that this research area was initiated in the early-1980s, are summarised. We principally divide the Perspective into two parts of oxidative addition and reductive elimination, along with a separate section concerning reactions where there is no change of uranium oxidation state in reactant and product but the reaction has the formal appearance of a ‘concerted’ reductive elimination/oxidative addition from the perspective of the net result. This body of work highlights that whilst uranium is capable of performing reactions that to some extent conform to traditional reactivity types, novel reactivity that has no counterpart anywhere else can be performed, thus adding to the rich palate of redox chemistry that uranium can mediate.
Scheme 1 The two classical 2-electron oxidative addition (O.A.)/reductive elimination (R.E.) couples – Ln = generic supporting ligands; M = metal; m = oxidation state; X–Y = substrate. |
The vast majority of classical oxidative addition/reductive elimination chemistry is dominated by the d-block, especially late transition-metals. Their electron-richness, diversity of easily accessible oxidation states and coordination sites, in combination with a richness of non-bonding d-electrons, render these metals ideal for supporting classical oxidative addition and reductive elimination. The most prevalent late transition-metals for application in catalysis are group 9 and 10 metals, especial Pd, Pt, Rh, and Ir.1 The ability of these metals to form strong M–L bonds and the large energy splitting of d-orbitals renders them capable of activating strong chemical bonds e.g. C–H, C–C etc., and their electron richness favours 2-electron type (a) oxidative additions/reductive eliminations. Apart from late transition-metals, although much less prevalent, oxidative addition/reductive elimination has been studied in main group chemistry resulting in fundamental contributions to organic/organometallic chemistry.1 For example, oxidative addition of chlorine to phosphorus trichloride to give PCl5, oxidative addition of RX (R = alkyl, aryl; X = halide) to magnesium to prepare Grignard reagents,3 oxidative addition at tin(II) to give tin(IV) derivatives,4 and more recently oxidative addition at low valent group 13 centres are all known and established.5
In comparison to d-block metals, f-block elements are traditionally recognised as being unable to mediate classical 2-electron oxidative addition/reductive elimination, due to their propensity to perform 1-electron redox couples, and highly ionic and thus weak M–E bonds (M = f-element; E = group 14–17 element). Instead, their organometallic chemistry is dominated by salt metathesis, insertion reactions of unsaturated bonds, 1-electron redox processes, and σ-bond metathesis from their highly polarising nature, and these reactivities have played a pivotal role in many important catalytic processes.6 One exception, however, is uranium, which is known to have one of the most diverse range of oxidation states amongst all f-elements in an organometallic context (+2,7 +3, +4, +5, +6). The range of accessible and variable oxidation states, along with the ability to form reasonably covalent and relatively strong U–E bonds, which is a result of availability of 5f- and 6d-orbitals to interact with ligand frontier orbitals, renders uranium the most promising f-element for conducting oxidative addition/reductive elimination reactions.
The history of well-defined, homogeneous uranium-mediated oxidative addition/reductive elimination dates back to the early 1980s. But until very recently it was a relatively obscure research topic and only a handful of discrete examples were reported. In the 21st century, mainly boosted by the introduction of redox non-innocent ligands and the concept of sterically induced reduction (SIR),8 the field has flourished and is gathering momentum. Both redox non-innocent ligands and SIR provide a viable route to manipulate f-elements, which inherently prefer 1-electron process, to participate in these overall n-electron (n ≥ 2) oxidative addition/reductive elimination processes. Together with the widely accessible oxidation states of uranium, the oxidative addition/reductive elimination chemistry mediated by uranium is often distinct to late transition-metal counterparts. Due to the importance of the oxidative addition/reductive elimination couple, and the unique role of uranium in the periodic table,9 this research area has great potential to extend the boundaries of organometallic chemistry as well as catalysis; thus, an up-to-date summary is warranted.
In this Perspective article, advances in uranium-mediated oxidative addition/reductive elimination, since the point that this research area was initiated in the early-1980s,10 are summarised. We principally divide the perspective into two parts of oxidative addition and reductive elimination, along with a separate section concerning reactions where there is no change of uranium oxidation state in reactant and product but the reaction has the formal appearance of a ‘concerted’ reductive elimination/oxidative addition from the perspective of the net result.11 This overview serves to highlight some similarities to transition metal chemistry, but also that uranium is capable of effecting some unique reactivity of its own.
In 1981, Finke and co-workers reported reactions between the U(III) complex [Cp*2U(Cl)(thf)] (1) and a series of haloalkanes.10a For chloroalkanes, these reactions yielded U(IV) bis-chloride (2) and U(IV) chloride alkyl (3) products, with cleavage of the C–Cl bond (Scheme 2). The oxidation state of uranium increases by one, whilst the R- and X-groups attach to two different U(IV) centres. Thus, the overall reaction can be described as type (b) oxidative addition. The free-radical nature of these reactions was indicated by the observation of R–R coupling products along with other radical decay products. If X is not chloride, ligand-scrambling processes were observed. Kinetic and mechanistic studies revealed that the active U(III) species ‘[Cp*2U(Cl)]’ is slowly produced by dissociation of the thf molecule from 1, whilst the subsequent atom-abstraction step from R–X is very fast.10b
Scheme 2 Oxidative addition of [Cp*2U(Cl)(thf)] (1) by haloalkanes.10a,b |
In related work, as a part of their systematic study of U(III) compounds, Marks and co-workers observed similar oxidative addition towards haloalkanes, but used the solvent-free U(III) trimer complex [Cp*2U(μ-Cl)]3 (4) (Scheme 3).10d The outcome of the reactions was reported to be dependent on the haloalkane substrate employed: with chloromethane the reaction produced two U(IV) products, [Cp*2UCl2] (2) and [Cp*2U(Cl)(CH3)] (3-Me), as expected as a clear-cut type (b) oxidative addition. However, with chlorobenzene [Cp*2UCl2] (2) was the only U-containing product along with other free-radical decay products. These results support the hypothesis that these uranium-mediated oxidative additions towards C–X bonds are free-radical processes.
Scheme 3 Oxidative addition of [Cp*2U(μ-Cl)]3 (4) by haloalkanes.10d |
In 2002, Scott and co-workers reported reactions between two equivalents of the U(III) complex [U(NN′3)] (5) (NN′3 = [N(CH2CH2NSiMe2tBu)3]3−) and halogens (Cl2, Br2, I2) to produce the corresponding U(IV) halide complexes [(NN′3)UX] (6) (X = Cl, Br, I) (Scheme 4).15 The reactions are formally type (b) oxidative additions, whilst the NN′3 triamidoamine ligand acts as an inert supporting ligand.
Scheme 4 Oxidative addition of [U(NN′3)] (5) by halogens.15 |
In 2009, Boncella and co-workers reported reactions between a U(V) bridging imido dimer (7) and Ph–E–E–Ph (E = S, Se, Te), which produced a series of U(VI) trans-bis-imide products (Scheme 5).16 Amongst the products, 9 and 10 can be considered to result from ligand redistribution reactions of the initial products 8. The reactions result in a +1 increase of the oxidation state for each uranium centre, cleavage of an E–E bond, and formation of U–E bonds, and thus can be classified as type (b) oxidative addition.
Scheme 5 Oxidative addition of U(V) bridging imide dimer (7) by PhE–EPh (E = S, Se, Te).16 |
In 1998, Burns and co-workers reported that a U(III) halide ‘ate’ compound, [Cp*2UCl(NaCl)(thf)2] (11), undergoes a 4-electron oxidative addition reaction overall towards azobenzene, to produce a U(VI) bis-imide (12) and the known U(IV) bis-chloride (2) as products (Scheme 7a).18 The reaction was postulated to proceed firstly via a 2-electron oxidative cyclometallation between 11 and azobenzene, yielding a chlorohydrazineuranium(V) intermediate; this intermediate is reduced by the U(III) starting material 11 yielding an azouranium(IV) intermediate, then a 2-electron oxidative ring-opening of the U–N–N three membered ring occurs to form the final product 12. It should be noted that 2 can be treated by sodium amalgam to reform 11. This is the first instance of azo-to-imide conversion in actinide organometallic chemistry.
Scheme 7 (a) 4-Electron oxidative addition of a U(III) compound by azobenzene to form U(VI) bis-imide 12; (b) proposed mechanism for the reaction.18 |
Another example of this type of reaction was reported by Evans and co-workers in 2013.19 In this case the U(III) allyl compound 13 was treated with 1 equivalent of azobenzene, to produce U(IV) bis-allyl (14) as well as the known U(VI) bis-imide (12) (Scheme 8).
Scheme 8 4-Electron oxidative addition of a U(III) allyl by azobenzene.19 |
Scheme 9 2-Electron oxidative addition of 15 by a N–N bond substrate.20 |
Based on the aforementioned oxidative additions towards NN and N–N bonds, U-mediated catalytic conversion of hydrazine to aniline and azobenzene was reported (Scheme 10).21 The presence of aniline as a product suggested the formation of U(IV) bis-anilide [Cp*2U(NHPh)2] during the reaction, however this species could not be detected.
Scheme 10 Catalytic conversion of hydrazine into aniline and azobenzene.21 |
One of only two examples of uranium-mediated complete cleavage of the NN bond was reported by Gambarotta and co-workers in 2002.24 The U(III) calix-tetrapyrrole compound 16 reacted with N2, with the assistance of [K(naphthalenide)], to produce a U(V)/U(IV) dinuclear mixed-valent compound 17, which has two anionic μ-nitrido (N3−) ligands (Scheme 11a). X-ray crystallographic characterisation of 17 revealed that the anion is centro-symmetric, and the two uranium centres are equivalent to each other. The N⋯N distance between the two nitrido centres is too long for there to be any N–N interaction. The overall formal redox couple of the reaction can be found in Scheme 11b. It is noteworthy that both the U(III) compound 16 and [K(naphthalenide)] on their own cannot reduce N2, thus a U(II) intermediate and/or a kind of cooperation between the alkali metal centre and the uranium centre is plausible for the unique reactivity.
Scheme 11 (a) Oxidative addition of the NN bond in N2 to uranium, and (b) the overall formal redox couple.24 |
The other instance of oxidative addition of low-valent uranium towards N2 can be found in Scheme 12. The U(III) compound [Cp*2U(BPh4)] (18) was reduced by KC8 in thf under an N2 atmosphere, affording a single crystal which was proven to be a U(IV) nitride 19 by a combination of DFT and X-ray crystallography. Unfortunately the reaction was not reproducible so neither spectroscopic nor elemental analysis could be provided for 19.25
Scheme 12 Oxidative addition of N2 to form a U(IV) nitride cluster.25 |
In 2008, Evans and co-workers reported a formal oxidative addition of a C–H bond at a U(III) centre.28 The U(III) hydride dimer [Cp*2U(μ-H)]2 (20), which was produced from a reversible bimetallic reductive elimination of H2 from a U(IV) hydride (vide infra),10c was reported to be able to activate the C–H bond of a methyl group on the Cp* ligand (Scheme 13). The formation of the U(IV) dinuclear tuck-in tuck-over compound (21) was confirmed by X-ray crystallography, and the H2 was probed by measuring the gas evolution by Toepler pump. Isotopic labelling experiments using [Cp*2U(μ-D)]2 (20-D) were hampered by H-D exchanging between protons of –CH3 and U–D.10c As a net result, the reaction leads to: (i) increase of uranium oxidation state by +1 for each of the two U centres; (ii) cleavage of two C–H bonds; and (iii) formation of two covalent U–CH2 bonds and two covalent U–H bonds. Thus, this reaction can formally be classified as an oxidative addition. The mechanism of the reaction is still ambiguous, but a U(II) intermediate is plausible, which would be produced by a U(III)/U(II) reductive elimination of H2 from 20, followed by U(II)/U(IV) oxidative addition towards C–H bonds to yield 21 (Scheme 14).
Scheme 13 Oxidative addition of a U(III) hydride by a Cp* C–H bond.28 |
Scheme 14 Possible mechanism of producing of 21, via a U(III)/U(II) reductive elimination and subsequently U(II)/U(IV) oxidative addition by a Cp* C–H bond. |
Although it does not fit the definition of oxidative addition, an example of ‘oxidative elimination’ of H2 from a U(III) hydroxide [Cp′′2U(μ-OH)]2 (Cp′′ = 1,3-(Me3Si)2C5H3) to yield U(IV) oxo [Cp′′2U(μ-O)]2 merits a mention here.29 The reaction was postulated to proceed via slow formation of a U(III)/U(IV) mixed-valent hydroxide oxo hydride [Cp′′2U(μ-O)(μ-OH)U(H)Cp′′2] species, which rapidly decays to the final product. The proposed mechanism was supported by kinetic data and isotopic labeling experiments.
An example of a more clear-cut uranium-mediated P4 activation that can be conclusively classified as oxidative addition was reported in 2011. Cloke, Green, and co-workers observed that the U(III) pentamethylcyclopentadienyl cyclooctatetraenyl complex [U(Cp*)(η8-C8H6-1,4-(SiiPr3)2)(thf)] (22) reacts with 0.5 equivalents of P4, producing a single product 23 (Scheme 15).31 The structure of 23 was comprehensively studied by X-ray crystallography as well as DFT computational methods: the planar, square P4 moiety was proven to be a dianion (P4)2−, and the oxidation states of both of the two uranium centres are +4. The reaction fulfils criteria for oxidative addition by: (i) cleavage of two P–P bonds in P4; (ii) increase of each uranium oxidation state by +1; (iii) formation of two new U–P covalent bonds per uranium ion.
Scheme 15 Oxidative addition of the U(III) complex 22 by P4.31 |
Some other oxidations of low-valent uranium compounds by group 16 elements (S, Se, Te) or equivalent reagents ({[K(18-crown-6)]2[Te2]}) have been reported, with the formation of high-valent uranium species with UE/U–E bonds.32 These reactions are oxidations, because they feature an increase of uranium oxidation state (by +2 or +1) and formation(s) of UE or U–E bond(s), but E⋯E interactions usually remain in the products.
In 2011, Bart and co-workers reported the reaction between a bis-(ene-α-diamide) U(IV) compound 24 and iodomethane (Scheme 16).36 In this reaction, the C–I bond in iodomethane is cleaved, whilst the uranium oxidation state does not change. One of the two redox non-innocent ene-α-diamide ligands in 24 is oxidised from its dianionic form (L2−) to a methylated monoanion form (MeL1−), with concomitant C–C bond formation. Although the reaction in Scheme 16 cannot be clearly defined as an oxidative addition, it does demonstrate the potential of a redox non-innocent ligand to take part in novel redox bond cleavage and formation reactions that are essential steps for a genuine oxidative addition.
Scheme 16 Reaction between bis-(α-diimine) U(IV) compound 24 and iodomethane.36 |
ortho-Iminoquinone is a relative of α-diimine, and three redox states are available for this ligand (Scheme 17). The U(IV) bis-amidophenolate compounds (series 26) were synthesised from salt elimination between UCl4 and the ligand bis-alkali metal salt.37 Compound series 26 were treated with PhICl2 or I2, resulting in the appearance of formal oxidative addition by the halogens (Scheme 18). However, the uranium oxidation states in the reactants and products are all the same (+4), while the ligands were oxidised from L2− (in series 26) to L1− (series 27 and 28) and so these reactions are not true type (a) oxidative additions. These reactions demonstrate that the L2−/L1− redox couple is more favourable than U(IV)/U(VI) or U(IV)/U(V) oxidations. The reaction to form 28 (Scheme 18b) is the closest to a clear-cut formal oxidative addition with the cleavage of an I–I bond and formation of two U–I bonds (but recall the uranium oxidation state does not change), whilst the reactions to form the 27 series (Scheme 18a) are more appropriately described as 1-electron chloride abstractions, since although two I–Cl bonds are broken there is no Cl–Cl bond in PhICl2 to be cleaved.38
Scheme 18 Formal oxidative addition of uranium by halogens in the presence of ortho-amidophenolate ligands.37 |
The pyridine(diimine) (PDI) ligand is another prevalent class of redox non-innocent ligand for transition-metal organometallic chemistry (Scheme 19). The capability of the PDI to host up to 4 electrons in combination with uranium has led to unique and fascinating chemistry.39
Very recently, the U(IV) compound 29 bearing a PDI3− ligand was synthesised by Bart and co-workers.40 Upon treatment with azobenzene, the U(V) bis-imide complex 30 containing a PDI0 ligand was produced (Scheme 20a). The overall 4-electron redox couple is summarised in Scheme 20b, where it can be seen that the uranium donates 1 out of the 4 requisite electrons, whilst the PDI ligand donates the other 3 electrons.
Scheme 20 Oxidative addition of a U(IV) centre by PhNNPh, in cooperation with the redox non-innocent PDI ligand.40 |
Bart and co-workers subsequently reported that another U(IV) PDI1− compound, 31, which is akin to 29, is also capable of executing oxidative additions completely based on the non-innocent PDI ligand (Scheme 21).41 The uranium oxidation states (+4) do not change throughout the reactions, whilst the 2-electron donations are made by the PDI3− trianionic free-radical ligand in 31, which is converted to a PDI1− monoanionic free-radical ligand in the products 32–34. To elucidate the mechanism of the oxidative additions, a crossover reaction between 31 and a 1:1 mixture PhS–SPh and PhSe–SePh was examined. A mixture of 34-S, 34-Se, and crossover product 34-S/Se were observed as products. Because ligand scrambling between 34-S and 34-Se was proven to be unlikely on the basis of control experiments, the formation of 34-S/Se is evidence of a free-radical mechanism.
Scheme 21 2-Electron oxidative addition based on redox non-innocent PDI ligands.41 |
The concept of SIR is also applicable to actinide compounds. In combination with the versatility of the range of oxidation states that uranium can adopt, multi-electron redox processes (>4-electron) are possible which can exceed the inherent 4-electron highest limit for the uranium-based redox couple (U(II)/U(VI), 4-electron).
The tris-pentamethylcyclopentadienyl U(III) compound [Cp*3U] (35) was first reported in 1997 by Evans and co-workers.46 The sterically-crowded 35 was found to be able to effect SIR towards the NN bond of azobenzene, to produce the known U(VI) bis-imide 12, along with Cp*2 (36) (Scheme 22).47 The overall 4-electron redox couple is listed in Scheme 22b. This oxidative addition led to cleavage of the NN bond, formation of two UN bonds, and an increase of uranium oxidation state from +3 to +6.
Scheme 22 Oxidative addition of a U(III) compound by azobenzene, with the assistance of 1-electron donation from a Cp*− ligand.47 |
In the same paper, it was also found that along with Cp*−, both the dianionic arene ligand (C6H6)2− and even the conventionally inert (BPh4)− ligand can act as electron donors.47 These reactions and their overall redox couples can be found in Scheme 23. Complex 37 belongs to the uranium arene inverted-sandwich compound family, in which the arene anion (Arn−) was reported to act as multi-electron donor towards organic or organometallic substrates.48 But the tetra-phenyl borate anion (BPh4)− in 18 was generally regarded to be redox inert, although some instances of B–Ph bond cleavage have been reported.49
Scheme 23 Oxidative additions of U(III) compounds by azobenzene, with (C6H6)2− and (BPh4)− acting as electron donors.47 |
The potential of (BPh4)− to act as a redox active ligand was further exploited shortly after the report of reactions in Scheme 23. In 2007, it was found that 38, which is closely related to 18, undergoes oxidative addition towards PhS–SPh. Here, both U(III) and (BPh4)− act as electron donors (Scheme 24).50 Further studies of lanthanide compounds consolidated the recognition of the (BPh4)− anion to act as a 1-electron donor via B–C bond cleavage to produce BPh3 and Ph as a free-radical.51
Scheme 24 Oxidative addition of a U(III) compound by PhS–SPh, with the assistance of 1-electron donation from the (BPh4)− ligand.50 |
Hydride (H−) can also play a role as a 1-electron donor, to form free-radical H that couples to yield H2. In 2007, multi-electron (4-, 6- and 8-electron) redox reactions mediated by actinide hydrides were reported.52 In this work, the known U(III) hydride dimer [Cp*2U(μ-H)]2 (20) was found to be able to conduct overall 4- or 8-electron oxidative additions towards PhE–EPh (E: S, Se) or PhNNPh (Scheme 25).
Scheme 25 Oxidative addition of a U(III) hydride by PhE–EPh and PhNNPh, with the assistance of 1-electron donation from a H− ligand.52 |
In 1981, as part of their work reporting the synthesis and properties of bis-pentamethylcyclopentadienyl actinide alkyls and hydrides, Marks and co-workers reported an equilibrium between [Cp*2U(H)(μ-H)]2 (41) and [Cp*2U(μ-H)]2 (20) (Scheme 26).10c Although the structures of these hydrides have not been characterised by X-ray/neutron diffraction until very recently,53 the reaction from left-hand-side to right-hand-side in Scheme 26 is the first example of reductive elimination for an actinide compound, which fits the definition of reductive elimination from all aspects: (i) cleavage of 2 U–H bonds; (ii) formation of an H–H bond; (iii) decrease of the oxidation state of each uranium from +4 to +3. This is a classical type (b) (bis-metallic) reductive elimination/oxidative addition couple according to Scheme 1.
Scheme 26 Bimetallic reductive elimination (R.E.)/oxidative addition (O.A.) equilibrium of U(IV) and U(III) hydrides.10c |
In 1982, Seyam and co-workers reported the reaction between uranyl dichloride [UO2Cl2] and 2 equivalents of phenyllithium at low temperature.10e The in situ generated UO2Ph2 species was allowed to warm to ambient temperature, yielding C–C bond-coupled biphenyl via a reductive elimination, along with UO2 (Scheme 27). However, neither the UO2Ph2 species nor the UO2 species were structurally authenticated. Nevertheless, the reaction fulfills all criteria of type (a) reductive elimination, and so far is the only genuine type (a) reductive elimination for any actinide compound. Other alkyllithium reagents (RLi, R = iPr, nBu, tBu, Me) were tested for the reaction, but instead of reductive eliminations, β-H elimination or free-radical H-abstraction were observed.
Scheme 27 Reductive elimination from a U(VI) uranyl centre.10e |
After decades of dormancy, in 2012 Bart and co-workers reported a redox non-innocent ligand induced C–C bond forming reductive elimination from a U(IV) homoleptic alkyl (Scheme 28a).54 Reaction between the U(IV) tetra-benzyl compound 42 and α-diimine led to 43, which remains a U(IV) compound, along with oxidatively coupled PhCH2CH2Ph. The redox couple can be found in Scheme 28b. A noteworthy point here is that the U(IV) centre is not involved in the redox process. An isotope-labelling crossover experiment proved that the reductive elimination follows an intramolecular mechanism. Reactions between 42 and redox-inert ligands were also tested, but no reductive eliminations were observed.
Scheme 28 Reductive elimination from a U(IV) alkyl, with the assistance of a redox non-innocent α-diimine ligand.54 |
Beside the α-diimine ligand class, it was also found that iminoquinone (44) can induce similar reductive elimination of a C–C bond from 42 (Scheme 29) to give 45.55 An isotope labelling crossover experiment using [U(CD2C6D5)4] (42-D) revealed that the reaction occurs in distinct steps, and a U(IV) tris-benzyl with monoanionic free-radical ligand was postulated as the intermediate.
Scheme 29 Reductive elimination from U(IV) tetra-benzyl, with the assistance of a redox non-innocent quinone ligand.55 |
A related reaction to the aforementioned non-innocent ligand-induced reductive eliminations was also reported by Bart and co-workers. In the presence of an organo-azide, the U(III) mono-alkyl complex 46, supported by two scorpionate hydrotris(pyrazolyl)borate ligands, was found to be able to yield bibenzyl as a result of intermolecular C–C coupling, as well as a U(IV) imide (47) (Scheme 30).56 The mechanism of these reactions was not discussed in the original work, but an initial intermolecular reductive elimination of 46 to produce PhCH2CH2Ph and a U(II) species is possible. The putative U(II) species could then be subsequently oxidised by azide to produce the U(IV) imide 47 and extruded N2. It should be noted, however, that this reaction defies any conventional classification because although oxidatively coupled bibenzyl is formed the uranium in fact undergoes a one-electron oxidation overall.
Scheme 30 C–C bond coupling in a reaction between a U(III) alkyl and an organic azide.56 |
Recent discoveries of the novel +2 oxidation state of actinide elements7,57 provides a new perspective from which to potentially view these redox reactions: an initial reductive elimination of a U(IV) centre to form a U(II) intermediate, which immediately undergoes an oxidative addition towards an incoming substrate (Scheme 31), thus can be rationalised as a concerted reductive elimination/oxidative addition. In this regard, the chemistry in Scheme 26 provides indirect evidence that such processes should be considered. However, it should be borne in mind that this hypothesis is currently limited to a theoretical construct and is open to debate since no supporting experimental evidence has been obtained.
Scheme 31 Concerted reductive elimination (R.E.)/oxidative addition (O.A.) via a hypothetical U(II) intermediate. |
In 2008, the U(IV) tuck-in tuck-over hydride 21 was found to be able to cleave the S–S bond of PhS–SPh, providing the U(IV) bis-phenylsulfide (40-S) (Scheme 32).28 The mechanism of the reaction was not clear according to the original paper, but concerted reductive elimination/oxidative addition is a plausible candidate: a reductive elimination to form C–H bond and a U(II) intermediate, which could then be followed by oxidative addition of a S–S bond.
Scheme 32 Concerted reductive elimination/oxidative elimination (R.E./O.A.) as a possible mechanism of formation of 40-S.28 |
Among the pair of reactions, oxidative addition is better developed compared to reductive elimination. This fact is partially due to the significant reductive potential of low-valent uranium, e.g. U(III). On the other hand, reduction of high-valent uranium centres (in oxidation state of +6, +5, or +4) to lower oxidation state often requires harsh conditions (e.g. alkali metals), and is usually outside the scope of the conventional potential range of R−/R couples, which is essential for the occurrence of reductive elimination. Furthermore, stable high valent uranium polyalkyls, which would capable of performing reductive elimination, are sparse, and although lower valent polyalkyl uranium species are known reductive elimination from those complexes would give oxidation states of uranium that are inaccessible under normal conditions (e.g. I and II). Thus, there is a dearth of suitable complexes for such reactivity experimentally. As a result, the barriers to oxidative addition is much lower than that of the reductive elimination, and in most cases the reaction is irreversible. This is quite different from that in transition-metal chemistry, in which the reversible oxidative addition/reductive elimination is better balanced. To overcome the higher energy barrier for the reductive elimination, involving higher uranium oxidation states (in particular +6, which is quite oxidising, as proven by initial studies of uranyl bis-alkyls10e) redox non-innocent ligands deserve future research effort. A step further is uranium mediated reversible oxidative addition/reductive elimination, which is highly desirable and can only be possible if the energy barriers for each of the two reactions are comparable. In this regard, the reversible oxidative addition/reductive elimination of 41/20 are notable since this represents a reversible type (b) oxidative addition/reductive elimination couple. Despite the impressive array of oxidative addition/reductive elimination reactions that have emerged, it is important to note that a classical type (a) oxidative addition has not yet been observed, and thus a reversible type (a) oxidative addition/reductive elimination couple has not been realised. On the other hand, uranium often mediates transformations that have no precedent anywhere else.
Bond cleavage and formation is the very essence of chemistry. Thus, another point of concern to uranium-mediated oxidative addition/reductive elimination is the scope of substrates. So far the most prevalent substrates for oxidative addition are azobenzene and diphenyl disulfide (or, less commonly, diselenide or ditelluride): here the NN bond or E–E (E = S, Se, Te) bonds are either weak or bear energetically low-lying antibonding orbitals and are thus easy to reductively cleave. For reductive elimination, thermodynamically favourable C–C bond formation is the most prevalent, with the assistance of redox non-innocent ligands. Further endeavours must extend the substrate scope to more synthetically useful C–C/C–H/H–H/C–O/C–F bonds for both oxidative addition and reductive elimination.
Due to the distinctive chemical properties of uranium, the mechanism of uranium-mediated oxidative addition/reductive elimination is intriguing and may differ significantly from those for late transition-metals. Mechanistic study is not only important to understanding nature of these reactions, but also can be a practical guide for developing catalytic systems. However, for most of uranium-mediated oxidative addition/reductive elimination the mechanism is poorly understood. Thus, mechanism elucidation of these reactions can be a new horizon for both experimental and theoretical chemists. A noteworthy point here is incorporation of the novel U(II) oxidation state into mechanistic explanations: although molecular U(II) compounds under ambient conditions were unknown until very recently, and can only be synthesised under harsh reducing conditions, this oxidation state may play a much more important role as intermediate/synthon than was previously thought, as hinted at by the equilibrium between U(IV)/U(III) hydrides 41/20.10c
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