Issue 42, 2015

Tuning radical reactivity using iodine in oxidative C(sp3)–H/C(sp)–H cross-coupling: an easy way toward the synthesis of furans and indolizines

Abstract

Molecular iodine was found to be an effective redox catalyst for the oxidative cross-coupling of carbonyl compounds with terminal alkynes. In this work, we demonstrated that iodine could tune radical reactivity through reversible C–I bond formation for controlling the reaction selectivity. This iodine catalysis protocol provided an easy way for the synthesis of various furans and indolizines.

Graphical abstract: Tuning radical reactivity using iodine in oxidative C(sp3)–H/C(sp)–H cross-coupling: an easy way toward the synthesis of furans and indolizines

Supplementary files

Article information

Article type
Communication
Submitted
03 Mar 2015
Accepted
17 Apr 2015
First published
17 Apr 2015

Chem. Commun., 2015,51, 8769-8772

Tuning radical reactivity using iodine in oxidative C(sp3)–H/C(sp)–H cross-coupling: an easy way toward the synthesis of furans and indolizines

S. Tang, K. Liu, Y. Long, X. Qi, Y. Lan and A. Lei, Chem. Commun., 2015, 51, 8769 DOI: 10.1039/C5CC01825K

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