Issue 42, 2015
From the journal:

Chemical Communications

Synthesis of chiral cyclobutanes via rhodium/diene-catalyzed asymmetric 1,4-addition: a dramatic ligand effect on the diastereoselectivity†

Ya-Jing Chen,a   Tian-Jiao Hu,a   Chen-Guo Feng*a  and  Guo-Qiang Lina  

* Corresponding authors

a CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China
E-mail: fengcg@sioc.ac.cn
Fax: +86 21 5080 7388
Tel: +86 21 5492 5081

Abstract

A highly diastereo- and enantioselective rhodium-catalyzed arylation of cyclobutenes for the efficient synthesis of chiral cyclobutanes has been developed. Chiral diene ligands exhibited excellent capability for the reaction diastereoselectivity control.

Graphical abstract: Synthesis of chiral cyclobutanes via rhodium/diene-catalyzed asymmetric 1,4-addition: a dramatic ligand effect on the diastereoselectivity

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Article information

DOI
https://doi.org/10.1039/C5CC02023A
Article type
Communication
Submitted
10 Mar 2015
Accepted
16 Apr 2015
First published
17 Apr 2015
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2015,51, 8773-8776

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Synthesis of chiral cyclobutanes via rhodium/diene-catalyzed asymmetric 1,4-addition: a dramatic ligand effect on the diastereoselectivity

Y. Chen, T. Hu, C. Feng and G. Lin, Chem. Commun., 2015, 51, 8773 DOI: 10.1039/C5CC02023A

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