V.
Croué
,
S.
Goeb
* and
M.
Sallé
*
Université d'Angers, CNRS UMR 6200, Laboratoire MOLTECH-Anjou, 2 bd Lavoisier, 49045 ANGERS cedex, France. E-mail: sebastien.goeb@univ-angers.fr; marc.salle@univ-angers.fr; Fax: +33 241 735 405; Tel: +33 241 735 439
First published on 20th March 2015
The metal-driven self-assembly strategy is well-established for the construction of discrete architectures featuring a cavity. The resulting molecular rings and cages are potentially useful as hosts for complementary guests. Recent years have seen growing interest in the introduction of given functionalities, including redox properties which, among others, allow modulating the ionic charge of the cavity. Depending on which subunit is electroactive, various situations can be encountered, with a global redox activity which is ligand- and/or metal-centered and which involves or not electronic interactions between the constituting units. In this feature article, we propose to survey those different situations by exploring some recent examples of the growing family of redox-active self-assembled rings and cages.
Dr Sébastien Goeb (right) was born in Schiltigheim (France) in 1979. He studied chemistry at the University of Strasbourg and obtained his PhD degree in Organic Chemistry in 2006 under the supervision of Drs Raymond Ziessel and Antoinette De Nicola. He then carried out two successive one year postdoctoral stays respectively with Prof. Felix N. Castellano at the University of Bowling Green (USA) and with Dr Jean-Luc Parrain at the Institut des Sciences Moléculaires de Marseille (France). He became Chargé de Recherche CNRS in the laboratory MOLTECH-Anjou in 2008. His research interests focus on the organic chemistry of photo- and/or redox-active supramolecular discrete architectures. |
Prof. Marc Sallé (middle) was born in Toulon (France) in 1963. He studied chemistry at the Ecole Nationale Supérieure de Chimie de Rennes (ENSCR) and at the University of Paris VI. He received his PhD degree in Organic Chemistry from the University of Angers in 1991 under the supervision of Professor Alain Gorgues. For this work he was awarded the Dina Surdin prize of year 1992. After a postdoctoral stay with Prof. Martin R. Bryce at the University of Durham (UK), he became Maître de Conférences at the University of Angers, where he was promoted to a professor in 1998. He has been a junior member of the Institut Universitaire de France (IUF). His research interests concern the organic chemistry of molecular materials and supramolecular chemistry associated with electro(photo)-active molecular systems. Prof. Marc Sallé is currently the director of the Laboratory MOLTECH-Anjou (Angers, France). |
Altogether, the diversity of the redox-active structures which can be attained by the metal-driven self-assembly methodology opens fascinating perspectives for various research topics, ranging from drug delivery, guest sensing, catalysis or even molecular electronics. We propose in this feature article to cover the most recent advances in this field.
Fig. 1 (a) Structure of self-assembled molecular hosts 1a–b; (b) cyclic voltammogram of 1b: C = 0.5 mM in CH3CN (Bu4NPF6 (50 mM)), scan rate 100 mV s−1, (c) structure of AdPt. |
Such a propensity of cage 1b to bind adamantane was very recently explored by J. T. Lippard and coworkers for drug delivery purposes.9 The authors developed a well-defined Pt drug delivery system based on the encapsulation of four adamantyl groups inside the cavity, each of them being appended with a Pt(IV) prodrug unit (AdPt). The cyclic voltammetry of assembly 1b·AdPt4 in water shows cathodic signals assigned to the triazine core (1b), as well as a less negative one corresponding to the irreversible reduction of Pt(IV). This scheme is confirmed by a chemical reduction of 1b·AdPt4 with ascorbic acid, which gives rise to a cisplatin release, beside 1-adamantylamine and succinic acid, providing therefore a proof of concept for a controlled delivery of cisplatin through reduction.
Finally, one can remind that tris(pyridyl)-triazine cages 1a,b present a good ability to encapsulate a wide variety of organic guests.1u This property was explored in the peculiar case of redox-active guests such as organic radicals of the nitronyl nitroxide type10 or ferrocene derivatives,11 whose redox properties are significantly modified upon encapsulation.
Fig. 2 (a) Orthogonal-bonding approach for the preparation of metalloprism 2; (b) cyclic voltammogram of 2: C = 1 mM in THF (Bu4NPF6 (0.1 M)), scan rate 100 mV s−1. |
Another rhenium-based family of redox-active polygons corresponds to rectangles 3a–f depicted by J. T. Hupp and coworkers (Fig. 3a).14 The latter incorporate four Re(I) corners which are organized into two pairs by doubly chelating planar 2,2′-bisbenzimidazolate ligands and which are bridged by rigid or semirigid ditopic symmetrical (LL) ligands. These systems were designed to study the balance between intramolecular through-space electronic communication (between facing LL ligands) vs. coordination-bond-mediated interactions. Spectroelectrochemical studies conducted at the −1 charge state of the rectangles (i.e. mixed-valence state with respect to the ligands), demonstrated that those systems are dominated by electronic interactions of the former type. A cyclic voltammetry study of rectangles 3a–f was carried out and shows reversible reduction waves that are assigned to stepwise one-electron reductions of the symmetrical LL ligands within the rectangle (for a representative example, see the case of compound 3d, Fig. 3b). No oxidative wave is observed and the reduction potentials appear substantially shifted to less negative potentials in comparison with free ligands, which is due to the electrostatic stabilization promoted by the rhenium cations over the negative reduced forms of the ligands.
Fig. 3 (a) Rhenium-based molecular rectangles 3a–f; (b) cyclic voltammogram of 3d in THF (Bu4NPF6 (0.1 M)). |
Fig. 4 (a) Metallosupramolecular squares 4 and 5. Cyclic voltammogram of 4 (b) and 5 (c) in CH2Cl2 (Bu4NPF6 (0.1 M)), scan rate 100 mV s−1. |
Though presenting remarkable photophysical and electrochemical characteristics as well as defined cavities, no guest encapsulation from the above-described PBI-based metalla-macrocycles was mentioned by the authors. It is only very recently that the same group designed a robust PBI-based metalla-assembly presenting host–guest properties.17 The very large M4L6 tetrahedron 6 (Fig. 5a) is assembled from an octahedral Fe(II) ion and a PBI ligand bearing 2,2′-bipyridine units on the imide positions. The resulting Fe4(PBI)6 tetrahedron exhibits a particularly rich electrochemical activity manifested by multiple redox processes. As seen above, PBI derivatives are electron-accepting moieties that can be successively reduced into radical-anion and dianion species. This is observed in the CV of 6 which exhibits reversible redox waves at E = −0.94 and −1.11 V vs. Fc/Fc+ respectively (Fig. 5b). Moreover, assembly 6 incorporates four electroactive Fe(bpy)32+ centers which are known to undergo reversible electrochemical oxidation and reduction processes. The reductions of the bpy units on each metal center are not simultaneous and occur according to three successive one-electron reduction processes, giving rise to a total of five reversible reduction waves for assembly 6. In addition, two oxidation waves are observed at E = +0.73 and +0.95 V vs. Fc/Fc+, assigned to the successive Fe2+ and PBI oxidation. It is worth noting that tetrahedron 6 is redox-stable for an impressive broad range of charges (from −16 up to +18), which corresponds to a total of 34 electrons which can be switched, simply by controlling the electrochemical potential. The authors attribute this efficient charge balance to the highly porous character of the large tetrahedron 6, which allows a suitable mobility of counterions during the redox switches. Another consequence of the large size of the cavity lies on the ability of 6 to encapsulate C60. Moreover, the size complementarity is strengthened by the well-established electronic affinity between C60 and the PBI moiety. Actually, the authors have shown by ESI-TOF mass spectrometry that not only one, but two fullerene units can be encapsulated within tetrahedron 6, which is one of the largest cavity ever described for the M4L6 family.
Fig. 5 (a) Self-assembly of metallosupramolecular tetrahedron 6 and C60 encapsulation; (b) cyclic voltammogram of 6: C = 0.1 mM in CH3CN (Bu4NPF6 (0.1 M)), scan rate 200 mV s−1. |
Fig. 6 (a) Synthesis of self-assemblies 7, 8 and 9; cyclic voltammogram of 7 (b), 8 (c), 9 (d): C = 0.20 mM in CH2Cl2 (Bu4NPF6 (0.15 M)), scan rate 25–250 mV s−1. |
With the aim of producing supramolecules that combine multiple properties, the same authors recently depicted multifunctional systems associating both an electro-active unit (i.e. Fc) and a crown-ether binding site in a same self-assembled macrocycle (Scheme 1).20 The single redox wave corresponding to the ferrocene unit in compound 10 remains reversible, and allows for the determination of the corresponding D values. Its binding properties with a dibenzyl ammonium salt were studied by 1H NMR and cyclic voltammetry. No change in the half-wave potential was observed upon complexation of the dibenzyl ammonium guest, indicating the lack of interaction between pendant Fc and crown-ether subunits. Nevertheless, the voltammogram shape of complex 11 compared to free 10 indicates as expected a lower D value upon complexation. Finally, efforts towards the synthesis of electroactive dendritic metalla-assemblies have to be mentioned.21 Based on a similar exo-functionalization approach as for the metalla-cycles depicted above, the same groups prepared a series of metallodendrimers of controlled size and shape, bearing both Fc and dendron functional groups. For instance, the reaction between 120° dendritic donors and 120° ferrocenyl acceptors resulted in hexagonal, hexafunctionnalized metallocycles 12a–c (Scheme 2).21d Their cyclic voltammograms reveal a unique redox wave corresponding to the reversible oxidation of the Fc units. Again, the authors could extract the values of the diffusion coefficients D from the CV experiments with, as expected, decreasing values when increasing the molecular weight.
A step further lies on the extension of this strategy from metalla-rings bearing Fc units to analogous 3D metalla-cages.22 The cuboctahedral complex 13 (Scheme 3) was obtained from a 120° Fc acceptor complex and a tritopic pyridyl ligand. Its redox properties were explored in detail. Each Fc unit exhibits a similar half-wave potential and no decomposition of the assembly is observed during the redox process. The D values extracted from the electrochemical measurements are similar to those obtained from the DOSY NMR experiment. Remarkably, the corresponding external diameter calculated from the Stokes-Einstein23 equation (6.7 nm) is close to the value obtained from the molecular force field model structure (6.9 nm). Finally, the diffusion coefficient allows assessing of the presence of twelve redox units on the metalla-cage, indicating that all the ferrocenyl moieties are oxidized simultaneously. In addition to these self-assembled rings and cages decorated with pendant redox active Fc units, P. J. Stang and coworkers described a rectangular assembly 14 which incorporates the Fc moiety as a constituting part of the ring skeleton (Fig. 7a).24 The electronic properties of 14 were studied by cyclic voltammetry (Fig. 7b) and show two reversible waves at E = +0.12 and +0.33 V vs. Fc/Fc+. The first redox process was assigned to a two-electron exchange centered on both Fc units and the second one, to the simultaneous oxidation of anthracenyl units. Interestingly, the authors could determine from the spectroelectrochemical analysis that the intermediate 142+ coexists in equilibrium with the neutral and the tetracationic forms.
Fig. 7 (a) Rectangular assembly 14; (b) cyclic voltammogram of 14: CH2Cl2 (Bu4NPF6 (0.1 M)), scan rate 200 mV s−1. |
J.-L. Zuo and coworkers described neutral complexes 15 and 16 (Fig. 8a).27 The latter was obtained in one step by the reaction of a mixture of cis and trans bis(pyrazole)-TTF ligands with Re(CO)5Cl. Their XRD analysis revealed that the TTF skeleton is bended in 15 and planar in metalla-ring 16. The high geometric constraints occurring in such small size self-assembled systems have of course a strong impact on the electronic integrity of the TTF unit (Fig. 8b). In both cases, the usual well-defined two-step redox behaviour of TTF cannot be recovered, due to the strong geometric constraint applied to the TTF core upon oxidation in the case of 15 and to an electronic coupling between the facing TTF redox units in the case of 16.
Fig. 8 (a) Assemblies 15 and 16; (b) cyclic voltammograms of 15 and 16: C = 0.5 mM in CH2Cl2 (Bu4NClO4), scan rate 100 mV s−1; (c) assembly 17. |
Another metalla-ring involving a metal carbonyl complex and a TTF derivative, namely vinylogous tetrathiafulvalene (TTFV), was described by D. Lorcy and coworkers (Fig. 8c).28 The latter is constructed from the self-assembly of a non-planar bispyridyl TTFV ligand with hexacarbonyl molybdenum in a 1:1 molar ratio. The electrochemical properties of metalla-square 17 which incorporates four redox-active units were studied by cyclic voltammetry. The system appears to be oxidized according to two successive processes at E = +0.48 and +0.74 V vs. SCE. The first one is attributed to the 0/•+ oxidation of the organic part, which is slightly shifted compared to the TTFV ligand precursor, the second wave being ascribed to the superimposition of both metal center oxidation with the •+/2+ ligand centered oxidation.
In the course of the studies conducted at Angers, related to the synthesis of electron-rich supramolecular discrete systems, we described recently several examples of metalla-rings and -cages whose cavities are made from TTF or its derivatives. For this purpose, several di- and tetra-topic ligands either designed from the parent TTF skeleton (18) or two of its well-known derivatives, namely bis(pyrollo)TTF (BPTTF)29 (19, 20) and the so-called extended-TTF (exTTF)30 (21) were synthesized (Scheme 4).
As a common feature, all of these ligands integrate a central sulfur-rich electron-rich framework. The first example of a metal-driven self-assembled system issued from the parent TTF corresponds to the octanuclear metalla-cage 22, which was prepared in collaboration with B. Therrien and colleagues (Fig. 9a). Reaction between tetratopic ligand 18 and dinuclear p-cymene oxalato ruthenium acceptor Ru1 afforded metalla-cube 22, whereas the reaction with dinuclear p-cymene quinonato complex Ru2 afforded tetranuclear plate 23.31 The selective formation of these two different architectures results from geometrical complementary interactions between 18 and the respective Ru1 and Ru2 counterparts. Two pyridyl nitrogen atoms located on the same dithiol unit in ligand 18 are separated by 6.7 Å, whereas both ruthenium centers are at a distance of 5.5 Å in complex Ru1 and at 7.9 Å in complex Ru2. Therefore, the good size matching between ligand 18 and Ru2 affords tetranuclear plate 23 whereas the smaller ruthenium acceptor Ru1 generates cage 22. Both assemblies were studied by cyclic voltammetry (Fig. 9b). Two characteristic redox waves corresponding to the TTF moiety are observed in plate 23 (E = +0.28 and +0.58 V vs. Fc/Fc+), shifted to higher potential in comparison to ligand 18 (E = +0.22 and +0.55 V vs. Fc/Fc+) as a consequence of the coordination to the metal centers. The electrochemical behaviour observed for metalla-cage 22 is significantly different since only one oxidation wave is observed, at E = +0.44 V vs. Fc/Fc+. This peculiar behaviour is assigned to the rigidity of the metalla-assembly which may alter the kinetics associated with the conformational changes which usually occur upon the electrochemical oxidation of TTF derivatives. It is indeed well-established that the TTF parent system undergoes severe conformational changes upon oxidation to heteroaromatic 1,3-dithiolium cations TTF˙+ and TTF2+. Whereas neutral TTF corresponds to a distorded boat-like structure, TTF˙+ is planar and TTF2+ is significantly twisted around the central C–C bond.25a,32 Consequently, if structural elements located on the periphery of the TTF skeleton prevent those conformational changes upon oxidation, the usual well-defined reversible two-step redox behaviour of TTF is not observed anymore. This is observed for instance with geometrically constrained tetrathiafulvalenophanes33 or TTF-based cage molecules,34 and is also observed in the case of metalla-cage 22. Another family of electro-active discrete self-assembled cages could be synthesized from ligand 18. The reaction of the latter with cis-blocked Pd(II) or Pt(II) complexes (i.e. cis-M(dppf)(OTf)2; dppf = 1,1′-bis(diphenylphosphino)ferrocene; OTf = trifluoromethane-sulfonate) in a 1:2 molar ratio afforded metalla-architectures 24a (Pt) or 24b (Pd).35 Both present an estimated hydrodynamic radii of ca. 16 Å as extracted from DOSY NMR experiments which, in addition to other spectroscopic data, well agrees with a M8L4 cubic geometry (Fig. 10a). Cyclic voltammetry experiments conducted on metalla-cages 24a and 24b show three reversible redox processes. Two are assigned to the TTF side walls and the third one to the corner ferrocene units. Interestingly, the latter can be used as an internal reference to address the number of electrons exchanged. The relative peak intensities of the three systems (i.e. 1/1/2) observed from the deconvoluted cyclic voltammogram (Fig. 10b) agree with two successive independent oxidations of the four TTF units at E = +0.30 and +0.60 V and of the eight ferrocenes at E = +0.80 V vs. Fc/Fc+, giving rise in total, to the reversible generation of sixteen positive charges on the periphery of the cavity. Molecular squares prepared by the coordination-driven self-assembly strategy are typically issued from the interaction between a linear ditopic ligand and a cis-blocked square planar metallic center. Depending on the length of the linear ligand or on its flexibility, the reaction can also lead to triangular systems beside the molecular square, both polygons being usually difficult to separate. Thus, the reaction of the linear N,N′-dipyridyl(BPTTF) ligand3619 with an equimolar ratio of cis-Pt(dppp)(OTf)2, (dppp = 1,3-bis(diphenylphosphino)propane), produces a mixture of triangle 25 and square 26 (Fig. 11a). Remarkably, in this case, each polygon could be easily isolated by selective precipitation.37 Both metalla-rings 25 and 26 were fully characterized by different methods.
Fig. 9 (a) Synthesis of metalla-cage 22 and metalla-plate 23; (b) cyclic voltammogram of 22 and 23: C = 0.5 mM in CH3CN (Bu4NPF6 (0.1 M)), scan rate 50 mV s−1. |
Fig. 10 (a) Cubic assemblies 24a and 24b; (b) deconvoluted cyclic voltammogram of 24a and 24b: C = 0.5 mM in CH3CN (Bu4NPF6 (0.1 M)), scan rate 20 mV s−1. |
Noteworthy, the ratio between their respective experimental radii (Rtriangle/Rsquare) extracted from DOSY NMR reaches a value of 0.80, in excellent agreement with the theoretical value. As usually observed for BPTTF derivatives, triangle 25 and square 26 exhibit two reversible oxidation waves (E = +0.70 and +1.00 V vs. Fc/Fc+) (Fig. 11b). In order to address the number of electrons exchanged in each process, ferrocene was added to the electrochemical solutions and used as an internal coulometric reference (i.e. three equivalents for triangle 25 and four equivalents for square 26). Analysis of the resulting respective peak intensities from the deconvoluted CV (Fig. 11b) suggests that the BPTTF side walls behave independently and that the metalla-rings are fully oxidized to their respective 256+ and 268+ stable states. Given the π-donating character of BPTTF derivatives, a peculiar feature of such polygons lies on the strong electronic density which is spread over the walls of the cavity, which in principle is favourable to bind to a complementary electron-poor guest within the cavity. On the other hand, the preparation of molecular and supramolecular hosts able to bind fullerene derivatives is a subject of intense interest.38 In this context, the binding affinity of 25 and 26 for electro-deficient C60 or C70 was monitored by UV-Vis titrations. The titration spectra as well as a Job's plot analysis (Fig. 11c) demonstrate a good binding affinity of triangle 25 for C60 (or C70) in a 1:1 stoichiometry. This result is supported by a good electronic complementarity of both components as well as by a suitable size matching between the cavity of 25 and a fullerene guest. The latter property is not satisfied in the case of square 26 whose cavity is much larger and which indeed does not exhibit any affinity for those fullerenes in UV-vis titration experiments.
With the aim to switch from electron-rich metalla-rings to metalla-cages, the tetratopic BPTTF-based ligand 20 (Scheme 4) was designed. The latter was reacted with square planar cis-Pt(PEt3)2(OTf)2 complex and the reaction converged in less than two hours into a single discrete prismatic cage 27 (Fig. 12a).39 The M6L3 formula was confirmed by ESI-MS mass spectroscopy and by an X-ray diffraction experiment (Fig. 12b). Cyclic voltammetry of metalla-cage 27 (Fig. 12c) reveals the presence of two successive oxidation waves, located at fairly low potentials (E = +0.43 and +0.62 V vs. Fc/Fc+) but poorly reversible due to a combination of steric and electronic factors. The guest binding capability of prism 27 was studied by UV-Vis spectroscopy with an electro-deficient compound (TCNQ-F4). The progressive addition of the guest to a solution of electron-rich M6L3 cage 27 leads to the formation of an inclusion complex with a 1:1 stoichiometry as extracted from a Job's plot analysis.
Fig. 12 (a) Metalla-prism 27; (b) X-ray crystal structure of 27; (c) cyclic voltammogram of 27: C = 0.6 mM in CH3CN (Bu4NPF6 (0.1 M)), scan rate 50 mV s−1. |
A third family of discrete metalla-assemblies that we have been developing40 is based on the exTTF framework. This π-donating skeleton exhibits unique electronic and geometrical properties that have been widely explored by N. Martín and coworkers in the construction of covalent hosts prone to encapsulate electro-deficient fullerene guests.38a
On this basis, tetrapyridyl-exTTF ligand 21 (Scheme 4) was synthesized in one step from pristine exTTF through a palladium catalyzed C–H arylation. A mixture of ligand 21 and cis-Pd(dppf)(OTf)2 in a 1:2 molar ratio afforded in only five minutes one discrete assembly 28a (Fig. 13a).40 Both species, ligand 21 and resulting M4L2 assembly 28a (Fig. 13b) could be characterized by X-ray diffraction. Ligand 21 displays the usual exTTF butterfly shape with a 86° dihedral angle between both 1,3-dithiol-2-ylidene mean plans. This curvature is amplified in the M4L2 container 28a with a dihedral angle of 56° which gives rise to an ovoid cavity whose size and shape are suitable for the inclusion of a planar guest. In particular, the formation of a 1:1 host–guest inclusion complex with perylene (Ka ≈ 3.9 × 103) could be demonstrated by 1H NMR, DOSY NMR and ESI-FTICR. Electrochemical properties of ligand 21 and container 28a were studied by cyclic voltammetry (Fig. 13c). In addition to a first oxidation wave attributed to the two-electron oxidation steps of each exTTF scaffold (E = +0.57 V vs. Fc/Fc+), container 28a exhibits a second oxidation process centered on the four ferrocene units (E = +0.80 V). Compared to ligand 21, the oxidation of exTTF in the complex is shifted to higher potentials due to the coordination to the metal center and appears irreversible presumably because of the rigidity of the self-assembly which prevents redox-driven conformational changes which usually occur with exTTF derivatives.
A promising development of self-assembled metalla-cages concerns their use as anti-cancer agents.1a,t,41 Based on the fact that various Ru(III) and arene Ru(II) complexes exhibit interesting cytotoxic effects, B. Therrien and colleagues have developed several families of water soluble cationic metalla-cages constructed from arene ruthenium complexes.1t,41a,c The authors have demonstrated the efficiency of such assemblies for increasing the solubility and cell permeability of drug-like molecules or photodynamic therapy (PDT) agents. Some of these metalla-assemblies were electrochemically studied. An illustrative example is given with the tetranuclear metalla-rectangle 29 (Fig. 14a),42 which is obtained from the reaction of a bipyridine ligand with a dinuclear arene ruthenium complex for which two Ru centers are bridged by a 1,4-benzoquinonato moiety. The redox properties of metalla-rectangle 29 have been studied by cyclic voltammetry (Fig. 14b). Compared to the dinuclear arene ruthenium precursor Ru2, rectangle 29 appears much easier to reduce, due to the presence of four positive charges in the metalla-assembly. Rectangle 29 undergoes three successive reduction waves at E = −0.68 (reversible, vs. Fc/Fc+), −1.39 (irr.) and −1.90 V (irr.) and no oxidation could be detected before electrolyte decomposition. Though the ligand orbitals are closely mixed with metal-based ones, these reduction processes can formally be assigned to electron injection occurring predominantly onto the quinonato bridging ligand.
A similar electrochemical behaviour (Fig. 14c) could be observed by P. Mukherjee and colleagues, from a 3D macrocyclic cage 30 (Fig. 14a) featuring the same bis-bidentate quinonato Ru complex Ru2, which is associated in this case with a tetra-imidazole ligand.43 Note that 2D analogous assemblies based on bis-imidazole ligands were also electrochemically characterized.44 Finally, the highly modular character of the stepwise strategy using half-sandwich piano-stool complexes for the construction of discrete electroactive polygons is illustrated by the possibility to change either the bridging dipyridyl ligand to a longer one as in rectangle 31,45 or the metal as in 32 which integrates an iridium metal complex instead of a ruthenium one.1q,46
Beyond Ru-based cages and as mentioned above with the encapsulation of a Pt(IV) prodrug AdPt,9 metalla-cages incorporating square planar Pt(II) and Pd(II) complexes have also been used as drug delivery vectors. This is the case with metalla-cages 33a–d recently described by J. D. Crowley and colleagues (Scheme 5a) which integrate a variety of functional groups on the outer surface of the host cage. They were prepared according to a very efficient modular approach based on the CuAAC ‘click’ reaction.47 Using this strategy, various functions were appended on the periphery of the cage, some being redox-active. The cyclic voltammetry study of compounds 33a–d in DMF shows basically a superposition of the redox contribution of each electroactive partner, be they reducible or oxidable. They display irreversible reductions at negative potentials (ca. E = −1.7 and −1.9 V vs. Fc*/Fc*+) assigned to the 2,6-bis(ethynyl)pyridine ligand framework as well as redox processes corresponding to the appended functional groups. In particular, the ferrocenyl-substituted cage 33a displays the usual reversible oxidation process of ferrocene at E = +0.5 V vs. Fc*/Fc*+ and no electronic communication was observed between the four pendant Fc units, as expected from their large spatial separation.
With a similar objective to decorate the outer surface of a metalla-structure, R. Yang et al. described the M12L24 sphere 34 (Scheme 5b) which integrates 24 thiophene units.48 The investigation of the electrochemical properties of 34 in DMSO is characterized by a reduction process at E = −1.06 V vs. Ag/AgCl. No information is provided regarding the oxidation and electropolymerization ability of this thiophene-rich system.
The case of square 35 (Scheme 6) depicted by A. J. Lees and colleagues49 is interesting since it encompasses three redox active centers, i.e. Ru(II)/Ru(III), Fc/Fc+ and the terpyridine ligand, all of them behaving independently. Two oxidation waves are observed and assigned to the Ru(II)/Ru(III) (E = +0.70 V vs. Fc/Fc+) and to the Fc corner (E = +0.88 V) respectively, whereas the reduction of the terpyridine fragment gives rise to two successive reduction processes. The comparison of the electrochemical behaviour of cyclen Ru-based triangle 36 and square 37 (Fig. 15a) described by J. R. Long and coworkers, provides an interesting case for using the electrochemistry tool in probing a molecular structure.50 Unlike triangle 25 and square 26 presented above and which exhibit similar cyclic voltammograms, quite different ones are observed for the triangular (cyclen)3[Ru3(4,4′-bpy)3](PF6)636 and the square (cyclen)4[Ru4-(4,4′-bpy)4](OTf)837. The former is oxidized following three distinct redox processes at E = +0.23, +0.37 and +0.48 V vs. Fc/Fc+ in acetonitrile, each of them corresponding to a Ru-centered one-electron exchange, whereas square 37 exhibits one single reversible four-electron process at E = +0.48 V and a high scan rate (1000 mV s−1). This difference is assigned to the more sterically constrained structure in the case of the triangle, which prevents any rotation of the pyridine rings with respect to each other and which favours electronic coupling by delocalization. Such a difference between homologous polygons nicely illustrates how the geometry of molecules built from the same components can have a direct impact on their electrochemical properties.
Because of their unusual topology and as illustrated with 36, metalla-triangles are appealing for the study of their redox properties. Another relevant example corresponds to Ru-based triangles 38a,b built from adenine ligands (Fig. 16). These metalla-rings, depicted by J. A. Thomas and coworkers,51 display a well-defined reversible electrochemical behaviour which is manifested by three Ru-based reversible oxidation processes, from which the authors could demonstrate the occurrence of two discernible mixed-valence states.
The case of the phenothiazine heterocycle is interesting since this system can be reversibly oxidized into a radical-cation at E = +0.73 V vs. SCE (acetonitrile) with the possibility of further oxidation or disproportionation. This favourable redox behaviour prompted G. H. Clever and colleagues to describe recently a phenothiazine-based coordination cage 39a.1c,52 The latter corresponds to an interpenetrated double cage based on eight phenothiazine ligands and four square-planar-coordinated Pd(II) cations (Fig. 17). Remarkably, the corresponding S-monooxygenated sulfoxyde and S-dioxygenated sulfone cages 39b and 39c could be successively obtained from 39a through a stepwise chemical oxidation with Cu(NO3)2·3H2O or, in the case of 39b, upon standing in air for two months. The three double cages 39a–c exhibit significant different shapes in the solid state as shown by their respective X-ray diffraction structures (Fig. 17b–d).52,53 Interestingly, titration with the oxidant[Fe(III)(bipyridine)3]3+, followed by reaction with water, shows that the intermediate cation radical 39a8˙+ reacts much faster with water compared to the cation-radical generated from the phenothiazine ligand precursor. This is ascribed to a cage effect which, upon oxidation, favours an intramolecular disproportionation. This property results in neutral and dicationic phenothiazine facets in the double cage, the latter dications being known intermediates in the production of S-monooxygenated sulfoxyde upon reaction with water. Finally, an interesting case concerns metalla-rectangle 40 described by C. N. Hsu and colleagues54 This tetranuclear iron thiolate complex can be electrochemically reduced according to three successive reversible redox processes (E = −0.28, −0.84 and −0.93 V vs. Fc/Fc+) (Fig. 18). It appears that in this rectangle, the 1,4-diisocyanobenzene ligand does not assist the electron communication between both iron thiolate cores, which behave independently at the first two-electron redox process (404+/402+). The second and third processes are assigned to two one-electron exchanges corresponding to 402+/40+ and 40+/400 couples respectively, redox states for which a weak exchange interaction seems to occur through the 1,4-diisocyanobenzene ligand. The most striking feature of this system, which could be demonstrated thanks to the single-crystal X-ray structures of 404+ and 402+, comes from their different cavity size, which appears larger in the tetracationic form than in the reduced one. Therefore, this work provides a nice illustration of how the size of a self-assembled redox-active system can be controlled thanks to a redox stimulus, opening therefore interesting perspectives in terms of electrochemical-triggering of guest binding.
Fig. 17 X-ray single-crystal structures of double cages 39a (b), 39b (c), 39c (d) (Metal = Palladium) and their corresponding constitutive ligands (a). |
Fig. 18 (a) Redox-controlled cavity modulation of rectangular complex 40; (b) cyclic voltammogram of 40: C = 0.2 mM in CH3CN (Bu4NPF6 (0.1 M)), scan rate 100 mV s−1. |
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