Issue 33, 2014
From the journal:

Journal of Materials Chemistry B

Anionic fibroin-derived polypeptides accelerate MSC osteoblastic differentiation in a three-dimensional osteoid-like dense collagen niche†

B. Marelli,‡§*a   C. E. Ghezzi,‡§a   A. Alessandrino,b   G. Freddib  and  S. N. Nazhat*a  

* Corresponding authors

a Department of Mining and Materials Engineering, McGill University, Montréal, QC, H3A 0C5, Canada
E-mail: showan.nazhat@mcgill.ca, benedetto.marelli@mail.mcgill.ca

b InnovHUB-Stazione Sperimentale per la Seta, Milano, Italy

Abstract

Incorporation of anionic fibroin derived polypeptides into dense collagen gels provided a dynamic, three-dimensional, tissue-equivalent matrix together with biochemical cues that resembled the role of the bone morphogenic growth factors commonly used to promote osteogenic differentiation of mesenchymal stem cells.

Graphical abstract: Anionic fibroin-derived polypeptides accelerate MSC osteoblastic differentiation in a three-dimensional osteoid-like dense collagen niche

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Article information

DOI
https://doi.org/10.1039/C4TB00477A
Article type
Communication
Submitted
26 Mar 2014
Accepted
23 Jun 2014
First published
24 Jun 2014

J. Mater. Chem. B, 2014,2, 5339-5343

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Anionic fibroin-derived polypeptides accelerate MSC osteoblastic differentiation in a three-dimensional osteoid-like dense collagen niche

B. Marelli, C. E. Ghezzi, A. Alessandrino, G. Freddi and S. N. Nazhat, J. Mater. Chem. B, 2014, 2, 5339 DOI: 10.1039/C4TB00477A

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