Gadolinium-loaded polychelating amphiphilic polymer as an enhanced MRI contrast agent for human multiple myeloma and non Hodgkin's lymphoma (human Burkitt's lymphoma)

Abstract

Liposomes, loaded with gadolinium (Gd) ions using different membrane-incorporated chelating lipids and functionalized with monoclonal anti-CD138 (syndecan-1) antibody were prepared. Nuclear Magnetic Resonance Dispersion (NMRD) analysis showed that use of the polychelating amphiphilic polymer (PAP) increases both the Gd content and the spin–lattice relaxivity of the Gd-loaded-PAP–liposomes as compared to Gd–DTPA–BSA equivalents. The potential application of contrast syndecan-1– and Rituximab–liposomes, for application as a novel minimally invasive diagnostic agent for multiple myeloma and non Hodgkin's lymphoma was investigated.