Issue 26, 2014
From the journal:

Organic & Biomolecular Chemistry

DABCO-mediated isocyanide-based multicomponent reaction: synthesis of highly substituted cyclopentenes†

Li-Rong Wen,*a   Ming-Chao Lan,a   Wen-Kui Yuana  and  Ming Li*ab  

* Corresponding authors

a State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China

b State Key Laboratory of Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, P. R. China
E-mail: liming928@qust.edu.cn, wenlirong@qust.edu.cn

Abstract

Highly substituted cyclopentenes can be accessed rapidly from isocyanides, aldehydes and malononitrile or ethyl cyanoacetate (AB2C2) using DABCO as a catalyst under solvent-free conditions at 40 °C within 30 min.

Graphical abstract: DABCO-mediated isocyanide-based multicomponent reaction: synthesis of highly substituted cyclopentenes

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Article information

DOI
https://doi.org/10.1039/C4OB00012A
Article type
Paper
Submitted
03 Jan 2014
Accepted
30 Apr 2014
First published
01 May 2014

Org. Biomol. Chem., 2014,12, 4628-4632

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DABCO-mediated isocyanide-based multicomponent reaction: synthesis of highly substituted cyclopentenes

L. Wen, M. Lan, W. Yuan and M. Li, Org. Biomol. Chem., 2014, 12, 4628 DOI: 10.1039/C4OB00012A

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