Matthias
Winkler
and
Michael A. R.
Meier
*
Laboratory of Applied Chemistry, Institute of Organic Chemistry, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany. E-mail: m.a.r.meier@kit.edu; Web: http://www.meier-michael.com
First published on 22nd April 2014
Olefin cross-metathesis of unsaturated fatty acid methyl ester (FAME) derived benzyl carbamates with methyl acrylate is described. The obtained by-product, an α,β-unsaturated ester, was further modified via thia-Michael addition reactions in order to synthesize branched AA-type or AB-type monomers for the preparation of polyesters, which are tuneable by oxidation. Cross-metathesis of fatty acid derived carbamates was used as a novel approach to prepare linear AB-type monomers, which can be used for the preparation of renewable polyamides PA11, PA12 and PA15. The necessary fatty acid carbamates were prepared by applying a catalytic Lossen rearrangement procedure. The presented synthesis strategy has potential for the bio-sourced preparation of monomers for the production of polyamides. All prepared polymers were fully characterized by NMR, SEC, and DSC analyses. Additionally, the Young's modulus of the prepared long-chain polyamide PA15 was determined.
These findings prompted us to search for novel catalytic procedures allowing the preparation of fatty acid based amino esters, which can be used to prepare renewable polyamides.
Thus, the olefin cross-metathesis of unsaturated fatty acid methyl ester (FAME) derived carbamates with methyl acrylate was investigated for the first time in order to synthesize renewable polyamides and polyesters. Moreover, utilizing all products of the respective metathesis reactions, the cross-metathesis by-products were also converted to valuable monomers and subsequently polymerized.
These findings prompted us to search for a possibility to perform efficient cross-metathesis reactions of fatty acid based substrates in order to obtain renewable polyamide precursors. In principle, instead of employing FAMEs in the cross-metathesis with methyl acrylate, the use of the corresponding amine would directly provide the desired amino FAME. However, cross-metathesis reactions of compounds having an amine moiety are still quite challenging and usually the amine function is protected.26 In this context, Bruneau and colleagues reported the cross-metathesis of 10-undecenenitrile with methyl acrylate.28 Subsequent hydrogenation of the cross-metathesis product yielded the desired AB-type monomer as a polyamide precursor. Recently, we reported the synthesis of fatty acid derived carbamates, which can be obtained in an environmentally friendly fashion via a catalytic Lossen rearrangement.29 The prepared methyl carbamates can be used to synthesize the corresponding amines by simple carbamate cleavage under basic conditions. Thus, a cross-metathesis of such carbamates and subsequent carbamate cleavage would enable the synthesis of the desired AB-type monomers as illustrated in Fig. 1. In order to enable a mild deprotection of the carbamate and hydrogenation of the double bond in one step, we used fatty acid derived benzyl carbamates as starting materials for the cross-metathesis reaction with methyl acrylate (Fig. 1). The catalytic Lossen rearrangements were performed according to our previously reported procedure utilizing TBD as a catalyst, methanol and dibenzyl carbonate.29 It is noteworthy that dibenzyl carbonate was synthesized by simple trans-esterification of dimethyl carbonate (a renewable and untoxic reagent), according to the procedure reported by our group earlier.30 An advantage of the Lossen rearrangement performed with dibenzyl carbonate and benzyl alcohol is the reaction efficiency. Thus, higher yields were obtained as in the synthesis of the corresponding methyl carbamates.29 Moreover, the excess of the required alcohol and carbonate was significantly reduced. On the other hand, the regeneration of the used benzyl alcohol and dibenzyl carbamate in order to perform the Lossen rearrangement in a sustainable manner is not as straightforward. However, the use of a Kugelrohr distillation apparatus allowed for a simple and efficient recycling of the benzyl alcohol and dibenzyl carbamate by distillation. It has to be noted that all Lossen rearrangements were performed with 20 mol% of the TBD catalyst. Interestingly, the reaction can also be carried out with lower catalyst loadings (5–10 mol%), though longer reaction times are needed.
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Fig. 1 Synthesis of renewable AB-type monomers via Lossen rearrangement, cross-metathesis, and subsequent deprotection. |
The cross-metathesis reactions were performed similar to a known procedure.16 Thus, all metathesis reactions were performed in bulk using the Hoveyda–Grubbs second generation catalyst (0.5 mol%) and an excess of the methyl acrylate. The desired products 4–6 were obtained in good yields (up to 91%) and were subsequently used for the preparation of the ω-amino FAMEs. In the case of the cross-metathesis of benzyl carbamate 3, a white precipitate was formed after a short reaction time, caused by self-metathesis, and only rather low yields (47–50%) were obtained. Improved yields of up to 80% were obtained if the reaction was performed at higher temperatures (60–65 °C, similar to the procedure reported by Slugovc et al. using ethyl acrylate at a reaction temperature of 75–80 °C26). Yields of up to 80% were also obtained if the reaction was performed on a smaller scale (1.5 g/3.4 mmol) under vigorous stirring. As a by-product, methyl undec-2-enoate 7 is formed, which can be further derivatized as described below (Fig. 3). The hydrogenation of the double bond and the cleavage of the benzyl carbamate were performed in one step. First, we used Pd/C as a convenient catalyst for heterogeneous hydrogenations and cleavage of benzyl carbamates. Although we employed a pressure of 20 bar of hydrogen at a temperature of 35 °C, the benzyl carbamate was not cleaved after two days. If Pearlman's catalyst (Pd(OH)2/C) was used instead, the hydrogenation as well as the cleavage of the carbamate was completed after 16 hours, providing the ω-amino FAMEs in very good yields and in high purity without further purification. The solvent used for the carbamate-cleavage/hydrogenation reaction appeared to be of crucial importance. The desired product was only obtained in high purity if alcohols, such as methanol or ethanol, were used. As an example, the 1H-NMR spectra of the benzyl carbamate 3, the cross-metathesis product 6, and the final amino FAME 10 are shown in Fig. 2, demonstrating the overall successful transformation of methyl erucate to the desired AB-type monomer. Subsequently, the prepared amino FAMEs were used in polycondensation reactions to prepare polyamides (PAs) with a varying carbon chain length using TBD or DBU as the catalyst. SEC analysis of P1, P2 and P3 revealed molecular weights of 14.9 kDa to 22.6 kDa and a dispersity of 1.73 to 2.20 (molecular weights were determined relative to narrow poly(methylmethacrylate) standards, see also ESI†). The melting points were determined by differential scanning calorimetry (DSC) and ranged from 169 °C to 186 °C (Table 1).
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Fig. 2 Comparison of the 1H-NMR spectra of the benzyl carbamate 3, the cross-metathesis product 6, and the amino FAME 10. |
Compared to commercially available polyamides, the melting points are in the expected range. For commercially available PA11 and PA12, melting points of 183 °C and 180 °C are reported, which are similar to the measured melting points of FAME based polyamides P1 and P2 (Table 1).32 Compared to PA11 and PA12, the amide frequency of PA15 is lower, and thus the melting point of the fatty acid derived polyamide P3 (Tm = 169 °C) is lower. When compared to PA16 with a melting point of 166 °C, the melting point of P3 is slightly higher due to an increased amide frequency.31
Both polymers P3 and PA16 are polyamides having an extended aliphatic segment and represent a class of interesting materials.33 Besides DSC, NMR and SEC analyses, we performed stress–strain measurements of the prepared long-chain polyamide P3 to determine the Young's modulus and compared the results to commercial PA11 and PA12 (for experimental details of the stress–strain measurements see ESI†). The measurements revealed a Young's modulus for P3 of 1480 MPa, which is lower than the modulus for the commercial PA11 and PA12. Apparently, the longer chain polyamides PA15 and PA16 having a lower amide group frequency have lower Young's modulus due to reduced hydrogen bonding. On the other hand, PA11 has a higher amide group frequency, thus having a stronger hydrogen bond interaction, but its Young's modulus is lower than that of polyamide 12 having a similar molecular weight. Herein, the slightly longer aliphatic chain segments have a significant impact on the Young's modulus. This effect can be explained by the different crystallinity of odd- and even-nylons.34 The same effect can be observed when the PA15 and P16 are compared with each other, although the difference in the Young's moduli is less pronounced.
As a by-product of the cross-metathesis of the fatty acid derived benzyl carbamates, an α,β-unsaturated ester, methyl undec-2-enoate 7, is obtained, which appeared to be an interesting starting material for further modifications. As is known, α,β-unsaturated carbonyl compounds undergo Michael type addition reactions; thus, the use of 7 as a Michael acceptor appears to be an appropriate synthetic strategy to transform the methyl undec-2-enoate to value-added compounds. In order to obtain monomers, we used 2-mercaptoethanol and methyl thioglycolate as Michael-donors to obtain monomers 11 and 12, respectively (Fig. 3).
Thia-Michael additions performed in bulk and with a small excess of the thiol (1.2 equivalents) provided the best results. Full conversion of 7 was achieved after stirring for 5 h at 50 °C using hexylamine (10 mol%) as the catalyst. The obtained monomer 11 was directly used in polycondensation reactions. The monomer 12 can be used in polycondensation reactions as well, if an appropriate diol or diamine is used. Thus, we transformed the obtained diesters from the metathesis of methyl oleate or -erucate to the corresponding diols 17 and 18 by standard reduction procedures (see ESI†) and used them as co-monomers (Fig. 4). In this way, we were able to use all products of the respective cross-metathesis reaction for the synthesis of renewable monomers. In previous studies, 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) showed very good performance as an organocatalyst for the synthesis of diverse polyesters and polyamides.35–37 In the case of monomers 11 and 12, this catalyst did not work since elimination of the thiol moiety occurred. However, using tin ethylhexanoate or titanium isopropoxide as a catalyst yielded the desired polyesters without the occurrence of elimination side reactions (Fig. 4). Size exclusion chromatography (SEC) revealed polymers with a molecular weight of 17.0–19.0 kDa and a dispersity of 1.52–1.90. The thermal properties of the prepared polyesters were studied using DSC, revealing melting points of −18.6 °C–15.5 °C.
As expected, the branched polyesters show low melting points due to their dangling side-chains. The polymer P6 displayed the highest melting point of 15.5 °C, since the employed long-chain C15 diol, derived from methyl erucate, provided increased crystallinity. The polymer P4 showed a Tg of 8 °C (Table 2).
Polymer | M n [kDa] | Đ | T m [°C] |
---|---|---|---|
P4 | 17.1 | 1.52 | T g = 8 |
P5 | 18.9 | 1.74 | −18.6 |
P6 | 18.0 | 1.90 | 15.5 |
P7 | — | — | 21 |
P8 | — | — | −5 |
P9 | — | — | 25 |
To modify the thiol containing polyesters (P4–P6), we performed some oxidation reactions with meta-chloroperoxybenzoic acid (mCPBA) in order to convert the sulfur atoms in the backbone of these polyesters to sulfones (P7–P9, Fig. 5, Table 2). SEC analysis of the oxidized polymers was not possible, since after the oxidation the polymers were not soluble in common SEC solvents (e.g. CHCl3, THF, DMAC, DMF, HFIP, or toluene).
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Fig. 5 Comparison of the 1H-NMR spectra before (top) and after (bottom) the oxidation of the sulfur containing polyester P4. |
Nevertheless, the slight solubility of the prepared polymers in chloroform allowed for 1H-NMR analysis of the oxidized products, which revealed the full oxidation of the sulfur, while no degradation of the polymer was observed (Fig. 5). DSC analysis of the polymers showed that the melting point of the polyesters increased due to this oxidation (Table 2).
Footnote |
† Electronic supplementary information (ESI) available: Detailed description of all experimental procedures. See DOI: 10.1039/c4gc00273c |
This journal is © The Royal Society of Chemistry 2014 |