Issue 34, 2013

N-chlorosuccinimide, an efficient peptidedisulfide bond-forming reagent in aqueous solution

Abstract

A novel method has been developed for the efficient formation of peptide disulfide bonds under aqueous conditions using N-chlorosuccinimide. Complete disulfide bond formation is achieved in 15 min with solvent mixtures containing water and acetonitrile.

Graphical abstract: N-chlorosuccinimide, an efficient peptide disulfide bond-forming reagent in aqueous solution

Supplementary files

Article information

Article type
Communication
Submitted
04 May 2013
Accepted
02 Jul 2013
First published
03 Jul 2013

RSC Adv., 2013,3, 14277-14280

N-chlorosuccinimide, an efficient peptide disulfide bond-forming reagent in aqueous solution

T. M. Postma and F. Albericio, RSC Adv., 2013, 3, 14277 DOI: 10.1039/C3RA43149E

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