Watson–Crick and Hoogsteen tri-base pairing: a co-crystal structure of a 2 : 1 complex of 6-isopropyluracil and adenine nucleobases

K. Radhakrishnan; Laxmi Narayana Burgula; Lal Mohan Kundu

doi:10.1039/C3RA40766G

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Watson–Crick and Hoogsteen tri-base pairing: a co-crystal structure of a 2 : 1 complex of 6-isopropyluracil and adenine nucleobases†

K. Radhakrishnan,^a Laxmi Narayana Burgula^a and Lal Mohan Kundu*^a

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* Corresponding authors

^a Department of Chemistry, Indian Institute of Technology Guwahati, North Guwahati, Assam, India
E-mail: lmkundu@iitg.ernet.in
Fax: +91-3612582349
Tel: +91-3612582326

Abstract

The formation of a tri-base pairing from free nucleobases is rare. A co-crystal structure obtained from an equimolar mixture of 6-isopropyluracil and adenine shows the formation of a tri-base pairing, where one molecule of free adenine is adhered to two molecules of the free pyrimidine nucleobase, involving both Watson–Crick and Hoogsteen base-pairing interactions.

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Article information

DOI: https://doi.org/10.1039/C3RA40766G
Article type: Communication
Submitted: 13 Feb 2013
Accepted: 20 Mar 2013
First published: 21 Mar 2013

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RSC Adv., 2013,3, 7282-7284

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Watson–Crick and Hoogsteen tri-base pairing: a co-crystal structure of a 2 : 1 complex of 6-isopropyluracil and adenine nucleobases

K. Radhakrishnan, L. N. Burgula and L. M. Kundu, RSC Adv., 2013, 3, 7282 DOI: 10.1039/C3RA40766G

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