Issue 20, 2013
From the journal:

RSC Advances

A novel antimicrobial agent reduces oxidative stress in cells†

Eliza James,a   Helena Viola,b   Livia Hool,b   Paul K. Eggers,a   Colin L. Raston*ac  and  Ramiz A. Boulos*ac  

* Corresponding authors

a Centre for Strategic Nano-Fabrication, School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia
E-mail: ramiz.boulos@uwa.edu.au
Tel: 61 8 6488 4422

b School of Anatomy, Physiology and Human Biology, The University of Western Australia M311, 35 Stirling Highway, Crawley, WA 6009, Australia

c School of Chemical and Physical Sciences, Flinders University, Bedford Park, SA 5042, Australia
E-mail: colin.raston@flinders.edu.au

Abstract

1,3,5-Tris[(1E)-2′-(4′′-benzoic acid)vinyl]benzene] (Ramizol™) is a potent and non-toxic synthetic antimicrobial agent, and we now establish that it is also a potent inhibitor of reactive oxygen species (ROS) generation, with similar antioxidant activity to α-tocopherol (Vitamin E), which is a standard antioxidantdrug. The results show that Ramizol™ decreases ROS to basal levels in PC12 cells and mouse and guinea pig myocytes, and demonstrate its protective nature from oxidative damage to the cells. The continuing challenge to discover antibiotics with no or few side effects makes Ramizol™ a very attractive candidate for the potential treatment of infections.

Graphical abstract: A novel antimicrobial agent reduces oxidative stress in cells

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Article information

DOI
https://doi.org/10.1039/C3RA40658J
Article type
Communication
Submitted
06 Feb 2013
Accepted
21 Mar 2013
First published
21 Mar 2013
This article is Open Access
Creative Commons BY license

RSC Adv., 2013,3, 7277-7281

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A novel antimicrobial agent reduces oxidative stress in cells

E. James, H. Viola, L. Hool, P. K. Eggers, C. L. Raston and R. A. Boulos, RSC Adv., 2013, 3, 7277 DOI: 10.1039/C3RA40658J

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