Organocatalytic asymmetric tandem condensation–intramolecular rearrangement–protonation: an approach to optically active α-amino thioester derivatives

Abstract

An unprecedented and conceptually novel chiral Brønsted base/Brønsted acid catalytic method for the enantioselective synthesis of α-amino thioesters through a tandem condensation–intramolecular rearrangement–protonation has been developed which provides a number of important synthetic building blocks in good yield and with moderate to good enantioselectivities.