Issue 2, 2012
From the journal:

MedChemComm

Inhibitory effect of bortezomib on human multiple myeloma cells when combined with epigallocatechin-gallate (EGCG) analogs

Sreedhar Pamu,a   Di Chen,b   Fred Morin,a   Congde Huo,ac   Qiuzhi Cui,b   Q. Ping Dou*b  and  Tak Hang Chan*ac  

* Corresponding authors

a Department of Chemistry, McGill University, Montreal, Quebec, Canada
E-mail: tak-hang.chan@mcgill.ca

b Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Department of Oncology, School of Medicine, Wayne State University, Detroit, MI, USA
E-mail: doup@karmanos.org

c Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong
E-mail: bcchanth@polyu.edu.hk

Abstract

EGCG analogs 6 and 8 with 1,3-benzenediol, but not 2 and 4 with a 1,2-benzenediol structure, can enhance the anti-cancer effects of bortezomib (BZM) on human multiple myeloma cells.

Graphical abstract: Inhibitory effect of bortezomib on human multiple myeloma cells when combined with epigallocatechin-gallate (EGCG) analogs

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Article information

DOI
https://doi.org/10.1039/C1MD00260K
Article type
Concise Article
Submitted
14 Oct 2011
Accepted
27 Oct 2011
First published
16 Nov 2011

Med. Chem. Commun., 2012,3, 229-232

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Inhibitory effect of bortezomib on human multiple myeloma cells when combined with epigallocatechin-gallate (EGCG) analogs

S. Pamu, D. Chen, F. Morin, C. Huo, Q. Cui, Q. P. Dou and T. H. Chan, Med. Chem. Commun., 2012, 3, 229 DOI: 10.1039/C1MD00260K

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