Abstract
A series of ruthenium complexes containing bis-benzimidazole derivatives have been synthesized and identified as able to target mitochondria and induce caspase-dependent apoptosis in cancer cells through superoxide overproduction.
* Corresponding authors
a
Department of Chemistry, Jinan University, Guangzhou, P. R. China
E-mail:
felixchentf@gmail.com
Tel: 020-85225962
b Department of Biology, The Chinese University of Hong Kong, Hong Kong, P. R. China
A series of ruthenium complexes containing bis-benzimidazole derivatives have been synthesized and identified as able to target mitochondria and induce caspase-dependent apoptosis in cancer cells through superoxide overproduction.
L. Li, Y. Wong, T. Chen, C. Fan and W. Zheng, Dalton Trans., 2012, 41, 1138 DOI: 10.1039/C1DT11950H
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