Issue 10, 2012
From the journal:

Chemical Communications

Hyperbranched polymers for molecular imaging: designing polymers for parahydrogen induced polarisation (PHIP)†‡

Kerstin Münnemann,*a   Michael Kölzer,a   Idriss Blakey,b   Andrew K. Whittakerb  and  Kristofer J. Thurecht*b  

* Corresponding authors

a Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany
E-mail: muenne@mpip-mainz.mpg.de
Fax: +49 6131 379100
Tel: +49 6131 379126

b Australian Institute for Bioengineering and Nanotechnology and Centre for Advanced Imaging, St Lucia, Queensland, Australia
E-mail: k.thurecht@uq.edu.au
Fax: +61 7 33463973
Tel: +61 7 33463864

Abstract

The first hyperpolarisation of polymers using parahydrogen induced polarisation (PHIP) is reported by hydrogenation of terminal alkyne groups in a biocompatible hyperbranched polymer. Signal enhancements of 1500-fold could be obtained depending on the structure of the polymer, thus opening new potential avenues for polymeric molecular imaging.

Graphical abstract: Hyperbranched polymers for molecular imaging: designing polymers for parahydrogen induced polarisation (PHIP)

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Article information

DOI
https://doi.org/10.1039/C1CC16077J
Article type
Communication
Submitted
30 Sep 2011
Accepted
06 Oct 2011
First published
17 Oct 2011

Chem. Commun., 2012,48, 1583-1585

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Hyperbranched polymers for molecular imaging: designing polymers for parahydrogen induced polarisation (PHIP)

K. Münnemann, M. Kölzer, I. Blakey, A. K. Whittaker and K. J. Thurecht, Chem. Commun., 2012, 48, 1583 DOI: 10.1039/C1CC16077J

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