Issue 10, 2012

Iron-catalysed, hydride-mediated reductive cross-coupling of vinyl halides and Grignard reagents

Abstract

An iron-catalysed, hydride-mediated reductive cross-coupling reaction has been developed for the preparation of alkanes. Using a bench-stable iron(II) pre-catalyst, reductive cross-coupling of vinyl iodides, bromides and chlorides with aryl- and alkyl Grignard reagents successfully gave the products of formal sp3–sp3 cross-coupling reactions.

Graphical abstract: Iron-catalysed, hydride-mediated reductive cross-coupling of vinyl halides and Grignard reagents

Supplementary files

Article information

Article type
Communication
Submitted
28 Jul 2011
Accepted
14 Oct 2011
First published
31 Oct 2011

Chem. Commun., 2012,48, 1580-1582

Iron-catalysed, hydride-mediated reductive cross-coupling of vinyl halides and Grignard reagents

B. A. F. Le Bailly, M. D. Greenhalgh and S. P. Thomas, Chem. Commun., 2012, 48, 1580 DOI: 10.1039/C1CC14622J

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