Issue 33, 2011

Photodimerisation of glycothymidines in solution and in micelles

Abstract

Glycothymidines were designed and synthesized as a new class of functional glycomimetics in which a photochemical [2+2] cycloaddition of the thymine moiety induces structural changes of carbohydrate presentation. To test if photodimerisation of these glycothymidines is feasible within an array of molecules, the photochemical reaction was investigated using NMR and NMR diffusion experiments in solution as well as in the supramolecular context of detergent micelles that mimic cellular membranes.

Graphical abstract: Photodimerisation of glycothymidines in solution and in micelles

Supplementary files

Article information

Article type
Communication
Submitted
01 Jun 2011
Accepted
28 Jun 2011
First published
19 Jul 2011

Chem. Commun., 2011,47, 9399-9401

Photodimerisation of glycothymidines in solution and in micelles

K. Schwekendiek, H. Kobarg, L. Daumlechner, F. D. Sönnichsen and T. K. Lindhorst, Chem. Commun., 2011, 47, 9399 DOI: 10.1039/C1CC13246F

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