Issue 8, 2008
From the journal:

Lab on a Chip

Soft lithography: masters on demand†

Mohamed Abdelgawad,a   Michael W. L. Watson,b   Edmond W. K. Young,ac   Jared M. Mudrik,b   Mark D. Ungrinc  and  Aaron R. Wheeler*bcd  

* Corresponding authors

a Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, ON, Canada

b Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, Canada
E-mail: awheeler@chem.utoronto.ca
Fax: +1 (416) 946-3865
Tel: +1 (416) 946-3864

c Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, University of Toronto, Toronto, ON, Canada

d Banting and Best Department of Medical Research, University of Toronto, 112 College Street, Toronto, ON, Canada

Abstract

We report an ultra-rapid prototyping technique for forming microchannel networks for lab-on-a-chip applications, called masters on-demand. Channels are produced by replica molding on masters formed by laser printing on flexible copper printed circuit board (PCB) substrates. Masters of various designs and dimensions can be individually or mass produced in less than 10 minutes. Using this technique, we have fabricated channels as narrow as 100 μm with heights ranging between 9 μm and 70 μm. Multi-depth channel fabrication is also reported, using a two-step printing process. The functionality of devices formed in this manner is verified by performing in-channel electrophoretic separations and culture and analysis of primary mammalian cells.

Graphical abstract: Soft lithography: masters on demand

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Article information

DOI
https://doi.org/10.1039/B804050H
Article type
Technical Note
Submitted
10 Mar 2008
Accepted
21 May 2008
First published
24 Jun 2008

Lab Chip, 2008,8, 1379-1385

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Soft lithography: masters on demand

M. Abdelgawad, M. W. L. Watson, E. W. K. Young, J. M. Mudrik, M. D. Ungrin and A. R. Wheeler, Lab Chip, 2008, 8, 1379 DOI: 10.1039/B804050H

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