Issue 21, 2006

trans-2,5-Disubstituted pyrrolidines: rapid stereocontrolled access from sulfones

Abstract

A direct and versatile route for the reliable synthesis of trans-2,5-disubstituted pyrrolidines from pyroglutamic acid is reported, which can be conducted at scale and without chromatographic purification of key intermediates.

Graphical abstract: trans-2,5-Disubstituted pyrrolidines: rapid stereocontrolled access from sulfones

Supplementary files

Article information

Article type
Communication
Submitted
10 Aug 2006
Accepted
19 Sep 2006
First published
03 Oct 2006

Org. Biomol. Chem., 2006,4, 3894-3897

trans-2,5-Disubstituted pyrrolidines: rapid stereocontrolled access from sulfones

M. G. Moloney, T. Panchal and R. Pike, Org. Biomol. Chem., 2006, 4, 3894 DOI: 10.1039/B611583G

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