Regioselective synthesis of pentathiepino-fused pyrroles and indoles
Abstract
Treatment of simple pyrroles, pyrrolidines and indoles with S2Cl2 and Dabco in chloroform at room temperature gives their fused pentathiepino derivatives 4, 6, and 8, in extensive cascade reactions; the reaction profile is changed and the regioselectivity enhanced when the S2Cl2 and Dabco are premixed and equilibrated before the heterocycle is added.