Studies on uracils: an efficient method for the synthesis of novel 1-allyl-6-(1′,2′,3′-triazolyl) analogues of HEPT

Abstract

An efficient synthetic method for preparing novel 1-allyl-6-(1′,2′,3′-triazolyl) analogues of HEPT, an anti-HIV reverse transcriptase inhibitor, is reported. The key step is based upon selective intermolecular cycloaddition of azide to acetylenes.

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