Flow injection determination of vitamin K₃ by a photoinduced chemiluminescent reaction

Abstract

The determination of vitamin K₃ using the coupling between a photochemical reaction and a chemiluminescent reaction in a flow system is described. The method is based on the photooxidation of ethanol sensitized by vitamin K₃ to yield hydrogen peroxide, which is monitored through the chemiluminescent reaction with luminol catalysed by hematin. The new approach allows the determination of vitamin K₃ in a wide concentration range (1 × 10^–7–5 × 10^–4 mol l^–1) with a throughput of 30 samples h^–1. The applicability of the method was demonstrated by the determination of vitamin K₃ in pharmaceutical preparations.

References

1. J. Kerns, S. Nagagathan, P. Dowd, F. M. Finn and B. Carr, Bioorganic. Chem., 1995, 23, 101.
2. M. Tomono and Z. Kiss, Arch. Biochem. Biophys., 1994, 314, 217.
3. National Formulary, American Pharmaceutical Association, Washington, DC, 11th edn., 1996, p. 201.
4. M. Tarek, M. Zaki, M. H. Fawzy and M. Mokhtar, Mikrochim. Acta, 1986, Part III, 321.
5. J. C. Vire and G. J. Patriarche, Analusis, 1978, 6, 395.
6. D. E. Ryan, T. P. Meyerhof and M. T. Fairhurst, Anal. Chim. Acta, 1976, 86, 195.
7. J. J. Berzas Nevado, J. A. Murillo Pulgarin and M. A. Gomez Laguna, Analyst, 1998, 123, 287.
8. J. C. Vire, N. A. El Malli, G. J. Patriarche and G. D. Christian, Talanta, 1988, 35, 997.
9. L. Wang, C. Ma, X. Zhang and Y. Xu, Microchem. J., 1994, 50, 101.
10. U. Manz and R. Mauer, Int. J. Vitam. Nutr. Res., 1982, 52, 248.
11. Y. Haroon, C. A. W. Schubert and P. V. Hauschka, J. Chromatogr. Sci., 1984, 22, 89.
12. A. J. Speek, J. Schrijver and H. P. Scheurs, J. Chromatogr., 1984, 301, 441.
13. S. M. Billedeau, J. Chromatogr., 1989, 472, 371.
14. J. R. Poulseu and J. W. Birks, Anal. Chem., 1989, 61, 2267.
15. J. P. Langenberg and U. R. Tjaden, J. Chromatogr., 1984, 305, 61.
16. V. W. Winkler and J. M. Yoder, J. Assoc. Off. Anal. Chem., 1973, 56, 1277.
17. X.-Q. Guo, Y.-B. Zhao and J.-G. Xu, Anal. Chim. Acta, 1997, 343, 109.
18. I. G. Torró, J. V. García Mateo and J. Martínez Calatayud, Analyst, 1997, 122, 139.
19. A. Townshend, Analyst, 1990, 115, 495.
20. K. Nakashima and K. Imai, in Molecular Luminescence Spectroscopy, ed. S. G. Shulman, Wiley, New York, 1993, pp. 1–23.
21. J. Ruzicka and E. H. Hansen, Flow Injection Analysis, Wiley, New York, 2nd edn., 1988.
22. M. Valcarcel and M. D. Luque de Castro, Flow Injection Analysis. Principles and Applications, Ellis Horwood, Chichester, 1987.
23. S. Suzuki, H. Nakuzawa and M. Fujita, Anal. Chim. Acta, 1989, 202, 247.
24. T. Pérez-Ruiz, C. Martínez-Lozano and A. Sanz, Anal. Chim. Acta, 1995, 308, 299.
25. T. Kuwana, Anal. Chem., 1963, 35, 1399.
26. M. S. Gandelman and J. W. Birks, Anal. Chem., 1982, 54, 2131.
27. M. S. Gandelman and J. W. Birks, J. Chromatogr., 1982, 242, 21.
28. M. S. Gandelman and J. W. Birks, Anal. Chim. Acta, 1983, 155, 159.
29. J. M. Poulsen and J. W. Birks, Anal. Chem., 1989, 61, 2267.
30. J. C. Vire, G. J. Patriarche and G. D. Christian, Anal. Chem., 1979, 51, 752.
31. B. Olson, Anal. Chim. Acta, 1982, 136, 113.
32. G. L. Long and J. D. Winefordner, Anal. Chem., 1983, 55, 712A.