DOI: 10.1039/A708546J
(Paper)
Reference Section for: J. Chem. Res. (S), 1998, 384-385
Photochemical Cleavage of Supercoiled DNA by N-Acyloxypyridine-2-thione Acridinyl Derivatives
(Note: The full text of this document is currently only available in the PDF Version )
Enzo Castagnino, Stefano Corsano, Roberta Barbaro and Patricia Carloni
Abstract
New acyl thiohydroxamates bearing an acridine moiety able to intercalate DNA double strand exhibit the capacity to cleave supercoiled DNA to linear DNA. EPR spin-trapping analysis has been employed to detect the formation of the carbon-centered radicals.
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