New acyl thiohydroxamates bearing an acridine moiety able to intercalate DNA double strand exhibit the capacity to cleave supercoiled DNA to linear DNA. EPR spin-trapping analysis has been employed to detect the formation of the carbon-centered radicals.
E. Castagnino, S. Corsano, R. Barbaro and P. Carloni, J. Chem. Res. (S), 1998, 384 DOI: 10.1039/A708546J
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