Microbiological Transformations. Part 14.¹ Microbiological Transformations of Derivatives and Open-chain Analogues of 1,2,3,4-Tetrahydroisoquinoline with the Fungus Cunninghamella elegans

Abstract

Incubation of N-benzoyl- and 1-methyl-N-benzoyl-1,2,3,4-tetrahydroisoquinolines with the mycelium of the fungus Cunninghamella elegans results in both benzylic hydroxylation and the formation of phenolic products; the 2- and 3-methyl substituted analogues gave products arising from C-1 hydroxylation.