DOI: 10.1039/A702128C
(Paper)
Reference Section for: Chem. Commun., 1997, 1049-1050
Measurement of the different affinities of the two halves of glycopeptide dimers for acetate
(Note: The full text of this document is currently only available in the PDF Version )
Ben Bardsley and Dudley H. Williams
Abstract
The titration of sodium acetate into solutions of the vancomycin group antibiotics eremomycin and chloroeremomycin has been studied by observing the downfield movement of the 1H NMR signals due to amide protons in the antibiotic binding pocket; this change in chemical shift has been used to determine the different affinities of the two halves of the dimers for acetate ligand.
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