High activity of an Fe–tfda (tfda = 2-aminomethyltetrahydrofuran-N,N-diacetic acid) complex for hydroxylation at the aromatic and alkane rings of 2′-deoxyguanosine in the presence of hydrogen peroxide

Abstract

An iron(III) complex with tfda (2-aminomethyltetrahydrofuran-N,N-diacetic acid) exhibits high activity for hydroxylation at the 8 and 2′ positions of deoxyguanosine in the presence of hydrogen peroxide; this demonstrates that a facile transformation from deoxyribonucleotide to ribonucleotide in vivo may be possible.