Issue 21, 1992

Internal aggregation during solid phase peptide synthesis. Dimethyl sulfoxide as a powerful dissociating solvent

Abstract

Internal aggregation within the peptide-resin matrix during solid phase peptide synthesis may be overcome by the use of dimethyl sulfoxide as solvent for both acylation and deprotection reactions.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1992, 1573-1575

Internal aggregation during solid phase peptide synthesis. Dimethyl sulfoxide as a powerful dissociating solvent

C. Hyde, T. Johnson and R. C. Sheppard, J. Chem. Soc., Chem. Commun., 1992, 1573 DOI: 10.1039/C39920001573

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