The repair of thymine and thymidine bromohydrins, models of damaged nucleic acids, by a copper(II) and ascorbic acid system
Abstract
Bromohydrins (1), (3), (4), and (5), damaged products of thymine derivatives, were repaired smoothly to regenerate the original thymine derivatives when exposed to ascorbic acid in the presence of a catalytic amount of Cu2+ in water at room temperature.