The hexahydro-1,5-methanoazocino[4,3-b]indole (2a) was converted into (±)-tubifolidine (6a)via a four-step synthetic sequence which involves cyclization of a thionium ion upon the 3-position of a 2,3-disubstituted indole as the crucial step.
M. Amat, A. Linares, M.-Luisa Salas, M. Alvarez and J. Bosch, J. Chem. Soc., Chem. Commun., 1988, 420 DOI: 10.1039/C39880000420
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