Racemization-free and efficient peptide synthesis by the carbodiimide method using 1-hydroxybenzotriazole and copper(II) chloride simultaneously as additives

Toshifumi Miyazawa; Toshihiko Otomatsu; Yoshimasa Fukui; Takashi Yamada; Shigeru Kuwata

doi:10.1039/C39880000419

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Racemization-free and efficient peptide synthesis by the carbodiimide method using 1-hydroxybenzotriazole and copper(II) chloride simultaneously as additives

Toshifumi Miyazawa, Toshihiko Otomatsu, Yoshimasa Fukui, Takashi Yamada and Shigeru Kuwata

Abstract

In carbodiimide mediated segment couplings, the simultaneous use of 1-hydroxybenzotriazole and copper(II) chloride as additives was found to give racemization-free peptides in high yields.

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DOI: https://doi.org/10.1039/C39880000419
Article type: Paper

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J. Chem. Soc., Chem. Commun., 1988, 419-420

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Racemization-free and efficient peptide synthesis by the carbodiimide method using 1-hydroxybenzotriazole and copper(II) chloride simultaneously as additives

T. Miyazawa, T. Otomatsu, Y. Fukui, T. Yamada and S. Kuwata, J. Chem. Soc., Chem. Commun., 1988, 419 DOI: 10.1039/C39880000419

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Journal of the Chemical Society, Chemical Communications

Racemization-free and efficient peptide synthesis by the carbodiimide method using 1-hydroxybenzotriazole and copper(II) chloride simultaneously as additives

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Racemization-free and efficient peptide synthesis by the carbodiimide method using 1-hydroxybenzotriazole and copper(II) chloride simultaneously as additives

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