Formation of the betaine (5) from methyl 4-(dimethylamino)butanesulphonate (4) proceeds by an intermolecular pathway and not by way of a cyclic eight-membered ring transition state; it is estimated that the effective concentration for the cyclic process is < 10–5M.
J. F. King and M. J. McGarrity, J. Chem. Soc., Chem. Commun., 1979, 1140 DOI: 10.1039/C39790001140
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