Issue 0, 1972

Synthesis of [1-(L-2-hydroxy-3-mercaptopropanoic acid)]oxytocin, a highly potent analogue of oxytocin

Abstract

An analogue of oxytocin containing a hydroxy-group in place of the primary amino-group was synthesized by coupling p-nitrophenyl L-2-acetoxy-3-benzylthiopropanoyl-L-tyrosinate with a heptapeptide. [1-(L-2-Hydroxy-3-mercaptopropanoic acid)]oxytocin possessed three times the oxytocic activity of oxytocin on the isolated rat uterus. Neurophysin did not bind the new analogue.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1972, 1946-1950

Synthesis of [1-(L-2-hydroxy-3-mercaptopropanoic acid)]oxytocin, a highly potent analogue of oxytocin

M. Wälti and D. B. Hope, J. Chem. Soc., Perkin Trans. 1, 1972, 1946 DOI: 10.1039/P19720001946

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