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Issue 44, 2016
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Peptide functionalized targeting liposomes: for nanoscale drug delivery towards angiogenesis

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Abstract

A novel affinity peptide S1 (LIDHEWKENYFPLSF) was screened out via a “one bead one compound” (OBOC) approach on a microarray device. It was identified that S1 could specifically recognize and bind to vascular endothelial growth factor receptor 2 (VEGFR2), which is an angiogenesis biomarker. Moreover, S1-functionalized liposomes (S1-LS) could achieve efficient nanoscale drug delivery under the conditions of VEGFR2-overexpression in vitro and in vivo. It was demonstrated that S1-LS would be a promising VEGFR2-targeting drug delivery system.

Graphical abstract: Peptide functionalized targeting liposomes: for nanoscale drug delivery towards angiogenesis

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Supplementary files

Article information


Submitted
20 Jul 2016
Accepted
11 Oct 2016
First published
14 Oct 2016

J. Mater. Chem. B, 2016,4, 7087-7091
Article type
Communication

Peptide functionalized targeting liposomes: for nanoscale drug delivery towards angiogenesis

Q. Han, X. Jia, Y. Qian, Z. Wang, S. Yang, Y. Jia, W. Wang and Z. Hu, J. Mater. Chem. B, 2016, 4, 7087
DOI: 10.1039/C6TB01823H

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