Theranostic body fluid cleansing: rationally designed magnetic particles enable capturing and detection of bacterial pathogens

M. Lattuada; Q. Ren; F. Zuber; M. Galli; N. Bohmer; M. T. Matter; A. Wichser; S. Bertazzo; G. B. Pier; I. K. Herrmann

doi:10.1039/C6TB01272H

Theranostic body fluid cleansing: rationally designed magnetic particles enable capturing and detection of bacterial pathogens†

M. Lattuada,‡^a Q. Ren,‡^b F. Zuber,^b M. Galli,^c N. Bohmer,^b M. T. Matter,^b A. Wichser,^b S. Bertazzo,^d G. B. Pier^e and I. K. Herrmann*^b

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^a Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland

^b Department Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), Lerchenfeldstrasse 5, 9014 St. Gallen, Switzerland
E-mail: inge.herrmann@empa.ch
Tel: +41 58 765 71 53

^c Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy

^d Department of Medical Physics and Biomedical Engineering, University College London, Malet Place Engineering Building, London, UK

^e Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA

Abstract

We report on theoretical and experimental considerations on bacteria capturing and enrichment via magnetic separation enabling integrated diagnosis and treatment of blood stream infections. We show optimization of carrier-pathogen interactions based on a mathematical model followed by an experimental proof-of-concept study along with investigations on the process safety.

Journal of Materials Chemistry B

Theranostic body fluid cleansing: rationally designed magnetic particles enable capturing and detection of bacterial pathogens†

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Theranostic body fluid cleansing: rationally designed magnetic particles enable capturing and detection of bacterial pathogens

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