Synthesis of a multifunctional manganese(ii)–carbon dots hybrid and its application as an efficient magnetic-fluorescent imaging probe for ovarian cancer cell imaging

Abstract

A novel magnetic-fluorescent manganese(II)–carbon dots hybrid nanoprobe conjugated with anti-HE4 antibody was successfully prepared for ovarian cancer cell targeting and bifunctional optical and MR imaging. In vitro and in vivo studies demonstrated the nanoprobe had high bio-compatibility, excellent tumor-targeting ability, superior MR and fluorescence imaging effects.