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Issue 25, 2015
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Photostable AIE fluorogens for accurate and sensitive detection of S-phase DNA synthesis and cell proliferation

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Abstract

Two azide-functionalized tetraphenylethene derivatives with AIE features are synthesized and used as fluorescent agents for detecting S-phase DNA synthesis and cell proliferation based on EdU assay. Compared to the Alexa-azide dye, a commercial DNA bioprobe, the AIE fluorogens show better photostability and sensitivity, making them promising alternatives.

Graphical abstract: Photostable AIE fluorogens for accurate and sensitive detection of S-phase DNA synthesis and cell proliferation

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Supplementary files

Article information


Submitted
12 Mar 2015
Accepted
14 Apr 2015
First published
14 Apr 2015

J. Mater. Chem. B, 2015,3, 4993-4996
Article type
Communication
Author version available

Photostable AIE fluorogens for accurate and sensitive detection of S-phase DNA synthesis and cell proliferation

Y. Zhao, C. Y. Y. Yu, R. T. K. Kwok, Y. Chen, S. Chen, J. W. Y. Lam and B. Z. Tang, J. Mater. Chem. B, 2015, 3, 4993
DOI: 10.1039/C5TB00458F

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