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Issue 11, 2014
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A cell-assembled, spatially aligned extracellular matrix to promote directed tissue development

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Abstract

A nanometer thick, micron scale-patterned interface on a polymeric material directs fibroblast proliferation into a highly aligned, confluent cell monolayer. These cells assemble fibronectin extracellular matrix (ECM) fibrils that are aligned with the pattern, and matrix alignment on the synthetic polymer surface is maintained throughout a decellularization process. Biologic relevance of this ECM-synthetic material composite is illustrated by directing oriented neurite outgrowth in register with the aligned matrix fibrils.

Graphical abstract: A cell-assembled, spatially aligned extracellular matrix to promote directed tissue development

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Article information


Submitted
30 Dec 2013
Accepted
03 Feb 2014
First published
03 Feb 2014

J. Mater. Chem. B, 2014,2, 1449-1453
Article type
Communication

A cell-assembled, spatially aligned extracellular matrix to promote directed tissue development

S. Singh, S. B. Bandini, P. E. Donnelly, J. Schwartz and J. E. Schwarzbauer, J. Mater. Chem. B, 2014, 2, 1449
DOI: 10.1039/C3TB21864C

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