Issue 11, 2014

Light-triggered CO release from nanoporous non-wovens


The water insoluble and photoactive CO releasing molecule dimanganese decacarbonyl (CORM-1) has been non-covalently embedded into poly(L-lactide-co-D/L-lactide) fibers via electrospinning to enable bioavailability and water accessibility of CORM-1. SEM images of the resulting hybrid non-wovens reveal a nanoporous fiber morphology. Slight CO release from the CORM-1 in the electrospinning process induces nanoporosity. IR spectra show the same set of carbonyl bands for the CORM-1 precursor and the non-woven. When the material was exposed to light (365–480 nm), CO release from the incorporated CORM-1 was measured via heterogeneous myoglobin assay, a portable CO electrode and an IR gas cuvette. The CO release rate was wavelength dependent. Irradiation at 365 nm resulted in four times faster release than at 480 nm. 3.4 μmol of CO per mg non-woven can be generated. Mouse fibroblast 3T3 cells were used to show that the hybrid material is non-toxic in the darkness and strongly photocytotoxic when light is applied.

Graphical abstract: Light-triggered CO release from nanoporous non-wovens

Supplementary files

Article information

Article type
22 Nov 2013
15 Jan 2014
First published
11 Feb 2014
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2014,2, 1454-1463

Author version available

Light-triggered CO release from nanoporous non-wovens

C. Bohlender, S. Gläser, M. Klein, J. Weisser, S. Thein, U. Neugebauer, J. Popp, R. Wyrwa and A. Schiller, J. Mater. Chem. B, 2014, 2, 1454 DOI: 10.1039/C3TB21649G

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