Jump to main content
Jump to site search

Issue 10, 2014
Previous Article Next Article

Fragmented polymer nanotubes from sonication-induced scission with a thermo-responsive gating system for anti-cancer drug delivery

Author affiliations

Abstract

Uniform purified long polymer nanotubes with crosslinked poly(glycidyl methacrylate) as the backbone and a pendant poly(N-isopropyl acrylamide) layer attached to the inner surface as a thermo-responsive gating system were synthesized by a two-fold “grafting-from” strategy inside cylindrical alumina nanopores. To adapt such long polymer nanotubes to be efficient nanocarriers for the intracellular delivery of anti-cancer drugs, a sonication-induced scission method was used to ‘cut’ the long nanotubes into short fragments. The discontinuous volume transition property in response to the temperature change for the pendant poly(N-isopropyl acrylamide) layer inside the nanotubes results in a reversible ‘closing/opening’ gating mechanism to control loaded drug release from the nanotubes. Using doxorubicin (DOX) as a model drug, in vitro thermo-responsive drug release behaviour and the related kinetics were studied in detail. The pristine fragmented polymer nanotubes were found to have good biocompatibility in the test with KB-3-1 cancer cells although toxic in their monomeric forms. More importantly, cell toxicity assays for DOX-loaded fragmented polymer nanotubes presented excellent temperature and concentration-dependent cytotoxicity with a low IC50 of 1.4 μmol L−1. These results indicated that such polymer nanotubes with a thermo-responsive gating system have potential as effective anti-cancer drug delivery vehicles.

Graphical abstract: Fragmented polymer nanotubes from sonication-induced scission with a thermo-responsive gating system for anti-cancer drug delivery

Back to tab navigation

Article information


Submitted
27 Oct 2013
Accepted
17 Dec 2013
First published
18 Dec 2013

This article is Open Access

J. Mater. Chem. B, 2014,2, 1327-1334
Article type
Paper
Author version available

Fragmented polymer nanotubes from sonication-induced scission with a thermo-responsive gating system for anti-cancer drug delivery

G. Chen, R. Chen, C. Zou, D. Yang and Z. Chen, J. Mater. Chem. B, 2014, 2, 1327
DOI: 10.1039/C3TB21512A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements