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Issue 34, 2013
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Cancer phototherapy in living cells by multiphoton release of doxorubicin from gold nanospheres

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Abstract

Doxorubicin is a widely used but toxic cancer chemotherapeutic agent. In order to localize its therapeutic action and minimize side effects, it was covalently conjugated to peptide-encapsulated gold nanospheres by click-chemistry and then photo-released in a controlled fashion by a multiphoton process. Selective treatment of a chosen region in a 2D layer of U2Os cancer cells is shown by driving photorelease with 561 nm irradiation at μW power. These results show promising directions for the development of practical applications based on nanocarriers that can ensure drug delivery with high spatial and temporal control.

Graphical abstract: Cancer phototherapy in living cells by multiphoton release of doxorubicin from gold nanospheres

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Supplementary files

Article information


Submitted
05 Jun 2013
Accepted
11 Jul 2013
First published
11 Jul 2013

J. Mater. Chem. B, 2013,1, 4225-4230
Article type
Paper

Cancer phototherapy in living cells by multiphoton release of doxorubicin from gold nanospheres

V. Voliani, G. Signore, O. Vittorio, P. Faraci, S. Luin, J. Peréz-Prieto and F. Beltram, J. Mater. Chem. B, 2013, 1, 4225
DOI: 10.1039/C3TB20798F

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